natrevgenet.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

Diversity matters. Nat Rev Genet 20, 495 (2019). doi.org/10.1038/s415...

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🎯 Calling all students & postdocs! Applications for #mbiosys25 fellowships are now open! 🧬 We have multiple fellowships to support ECRs attend the meeting and join us in Chile for cutting-edge discussions in gene regulation & functional genomics. 📆 Apply by April 30! 🔗 molbiosystems.com

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ICYMI: New online! Adapting systems biology to address the complexity of human disease in the single-cell era

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ICYMI: New online! Challenges and solutions to the sustainability of gene and cell therapies

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ICYMI: New online! Integrating model systems and genomic insights to decipher mechanisms of cancer metastasis

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FYI: New online! Decoding cell–cell communication using spatial transcriptomics

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FYI: New online! Intrinsically disordered regions as facilitators of the transcription factor target search

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FYI: New online! Tracking protein binding to cis-regulatory elements with PRINT

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Free to read here: rdcu.be/ecTna

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Currently, there's a lot of interest in quantitative models that would help us understand and predict features of the complex cellular systems that underlie human health and disease - think about virtual cells, for example. On can trace some of these ideas back to the early days of systems biology.

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This month we introduce a Collection on lived experience expertise in mental health research. The centerpiece is 11 interviews with lived experience experts who generously share their personal experiences with mental health challenges & explain why they decided to contribute to clinical research.

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ICYMI: New online! Beyond the black box with biologically informed neural networks

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ICYMI: New online! Progress in understanding the vertebrate segmentation clock

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The success of genomics has relied on open data-sharing practices since the Human Genome Project. But as research evolves, are we at risk of losing this collaborative mindset?

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So you want to write an opinion piece... We've edited hundreds over the years, and in our March editorial we share our top tips www.nature.com/articles/s42... Here's a thread with some highlights 🧵

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Adapting systems biology to address the complexity of human disease in the single-cell era go.nature.com/3XBo6Vh #Review by @davidsebfischer.bsky.social, Martin A. Villanueva, Peter S. Winter & Alex K. Shalek @broadinstitute.org @mitofficial.bsky.social @ragoninstitute.bsky.social

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How do we capture discrepancies between the biology of human tissues and experimental models? And what can we do to reduce this "translational distance"? A multiscale systems biology framework can be used to study disease mechanisms at a given spatiotemporal scale.

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New online! Adapting systems biology to address the complexity of human disease in the single-cell era

submitted 9 days ago • 0 comments

New online! Challenges and solutions to the sustainability of gene and cell therapies

submitted 9 days ago • 0 comments

New online! Integrating model systems and genomic insights to decipher mechanisms of cancer metastasis

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FYI: New online! Genomic data sharing: you don’t know what you’ve got (till it’s gone)

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Thrilled to share our latest publication in @natrevgenet.bsky.social. We explore how deep learning models infused with prior knowledge—biologically-informed neural networks or BINNs—offer better predictive accuracy and interpretability in multi-omics data analysis. www.nature.com/articles/s41...

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New online! Beyond the black box with biologically informed neural networks

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New online! Progress in understanding the vertebrate segmentation clock

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The genetics of obesity: from discovery to biology go.nature.com/4h5x9os #WorldObesityDay Free to read here: rdcu.be/eb3bF

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1/ Our review on sequencing-based #microbiome analysis is in the Dec 24 issue of Nature Reviews Genetics. We explore DNA/RNA-sequencing approaches for studying microbiome structure and function, highlighting the biological insights sequencing-based microbiome research offers. go.nature.com/3XFqonu

submitted 120 days ago • 3 comments

As my first post on @bsky.app I am happy to share our paper in Nature Reviews Genetics on how biobanking coupling genetic data with phenotypes at scale shapes precision medicine and global health go.nature.com/3AS54C0. Grateful to Scott Gallagher and Anji Musick for the All of Us Research Program.

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A Review in Nature Reviews Genetics discusses how biobanks facilitate genetics research towards advancing precision medicine and overviews potential solutions to their current limitations. https://go.nature.com/3OLSnw1 🔒

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A Review in Nature Reviews Genetics examines computational and statistical challenges that must be addressed for the rigorous construction of interpretable epigenetic clocks at cell-type and single-cell resolution. https://go.nature.com/3EKFgt0 🔒

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Check out this nice "Tools of the Trade" piece in Nature Reviews Genetics written by Ankit Agrawal on our NiCo algorithm for the analysis of single-cell spatial transcriptomics data from platforms like Xenium, MERSCOPE, seqFISH etc. Feel free to reach out for advice. www.nature.com/articles/s41...

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ICYMI: New online! Decoding cell–cell communication using spatial transcriptomics

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ICYMI: New online! Intrinsically disordered regions as facilitators of the transcription factor target search

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ICYMI: New online! Tracking protein binding to cis-regulatory elements with PRINT

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Our March 2025 issue is now live: go.nature.com/41qMAms Topics include: GWAS of copy number variation; computational models of the splicing code; a genetics-focused review of biobanks; and DNA recording

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FYI: New online! Spatial miRNomics: towards the integration of microRNAs in spatial biology

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Our Associate Editor Henry Ertl is attending #AGBTGM #AGBT25 - if you want to chat reviews with him, drop us a line!

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Review: Targeted genome-modification tools and their advanced applications in crop breeding www.nature.com/articles/s41... (free: rdcu.be/dFHti) 🧬🖥️

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FYI: New online! Integrating ELSI study teams in paediatric genomic research efforts

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ICYMI @katholt.bsky.social and I wrote a piece on genomic data sharing and the legacy of foundational HGP documents, the Bermuda Principles and the Ft Lauderdale Agreement. We ask: What do we want science to look like? Who should be included or excluded from doing science? bsky.app/profile/natr...

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New online! Decoding cell–cell communication using spatial transcriptomics

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Very happy to see that our review on gene regulatory networks is being featured by Nature Reviews Genetics and that it inspired its cover! 🥳 doi.org/10.1038/s415...

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In Nature Reviews Genetics: "Plant pattern recognition receptors: from evolutionary insight to engineering" rdcu.be/dZPdL ...summarizes both established and innovative approaches to leverage genomic data and translate resulting evolutionary insights into engineering PRR recognition specificities.

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Nature Reviews Genetics editors asked me to write about an inspiring article, and one immediately came to my mind. Whether you've read the original article or not, I hope you'll take 5-10 minutes to read my professional and personal perspective rdcu.be/dpwTH . Weblink: www.nature.com/articles/s41...

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Really outstanding review of the DNA science of Denisovans out now in Nature Reviews Genetics, by Stéphane Peyrégne, Viviane Slon and Janet Kelso. Highly recommended if you follow this field. t.co/7BtjeUAkrg

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Biobanking with genetics shapes precision medicine and global health | Nature Reviews Genetics www.nature.com/articles/s4...

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Our review is out in Nature Reviews Genetics! rdcu.be/d5AY2 We show how phylogeny-based methods can resolve the problem of non-independence in genomic datasets. These methods must be considered an essential part of the comparative genomics toolkit. @lauriebelch.bsky.social @stuwest.bsky.social

submitted 70 days ago • 5 comments