paulhoward.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

THIS IS HUGE! Researchers at Stanford University have developed a dual-antibody treatment that remains effective against ALL SARS-CoV-2 variants by targeting a less-mutable part of the virus. This breakthrough could lead to longer-lasting therapies that OUTPACE viral evolution. 🧪🧵⬇️

submitted 3 days ago • 599 comments

This is an easy-to-use delirium screening tool Approx a third of pl I see are delirious Not always florid agitation so easy to miss But causes distress Intriguingly, often "disgruntled with their care" which resolves once delirium addressed (eg just pulling back the opioid or pregabalin a little)

submitted 3 days ago • 0 comments

On International Women's Day we are highlighting research by Women in Anaesthesia, Critical Care & Pain Medicine. Check out this paper on Tranexamic Acid by Gurunathan et al www.bjanaesthesia.org/article/S000...

submitted 4 days ago • 0 comments

Just so you know, up to 60,000 children go blind from measles every year

submitted 8 days ago • 40 comments

NEW: One million children will go untreated for severe malnutrition, up to 166,000 people will die from malaria and 200,000 more children will be paralyzed by polio over the next decade, internal memos estimated. The USAID programs were cut anyway. By Brett Murphy and @annamaria.bsky.social

submitted 9 days ago • 89 comments

If you are reeling from Trump & Vance's disgusting performance towards Zelensky last night, might you consider donating to www.hospiceukraine.com, the tiny charity I set up with Henry Marsh to support local Ukrainian palliative care teams? We delivered this Land Rover to a rural hospice in Dec...

submitted 11 days ago • 36 comments

⚡️ 'There is an aggressor, which is Russia,' says Macron after Zelensky-Trump clash. "There is an aggressor, which is Russia, and an attacked people, which is Ukraine," French President Emmanuel Macron said after President Volodymyr Zelensky and President Donald Trump's clash at the White House.

submitted 12 days ago • 53 comments

Measles was eliminated in the US in 2000 because of vaccines! I did not know a single person who had measles growing up and have never seen a case of measles as a doctor. Outbreaks and deaths are now happening because of people like RFK Jr minimizing measles and discoursing vaccination!

submitted 14 days ago • 2 comments

Congratulations to the International Society of Drug Bulletins (ISDB) on the launch of their new website: isdbweb.org ISDB is a worldwide network of bulletins and journals on drugs and therapeutics that are financially and intellectually independent of the pharmaceutical industry #medsky #pharmsky

submitted 16 days ago • 0 comments

"They seemed genuinely surprised that I found the system so upsetting"

submitted 20 days ago • 0 comments

We are here : "We will consider anonymity when a clinical scenario is particularly important to share and learn from, or to protect an author’s safety—for example, if they are a whistleblower." Responding to fear and magical thinking in the US, a nice editorial in the @bmj.com.

submitted 21 days ago • 0 comments

Attached RCT found bezafibrate effective for itch due to various fibrosing cholangopathies; editorial pointed out its easier to use than rifampicin Is anyone aware of experience/reports using bezafibrate for cholestatic itch due to malignancy? I can't find any www.gastrojournal.org/article/S001...

submitted 21 days ago • 1 comment

Please consider signing this if you consider the way people are being treated is wrong, and/or decimating epidemiology during the overlap of a pandemic and a panzootic is just plain f***ing insane... chng.it/f8SnXbcYZn

submitted 23 days ago • 2 comments

I arrived in the UK on a spouse and dependents visa, with “no recourse to public funds” stamped in my passport. I’ve given back to the young people, music industry, and research base of this country ever since, been a citizen for over two decades, and paid a hell of a lot of tax. I am an immigrant.

submitted 24 days ago • 4 comments

🍫 Will climate change end chocolate? Cocoa yields may increase in parts of Nigeria & Cameroon but decline in Ghana & Côte d'Ivoire as rainfall & temperatures shift. Future chocolate supplies depend on how cocoa adapts. 🔗 www.sciencedirect.com/science/arti... #ClimateChange #Cocoa #SciComm 🧪

submitted 25 days ago • 5 comments

Interesting reminder of the importance of measles vaccination. In addition to fatalities at the time, I hadn't realised that SSPE affects roughly 1 in 600 to 1 in 1300, depending on age (a fatal neuro-degenerative condition occurring in teenage years for those infected in childhood)

submitted 25 days ago • 0 comments

Today is International Day of Women & Girls in Science. Marie Curie, the first woman to win a Nobel Prize. Her contributions have left an indelible mark on the world of science & health & continue to inspire generations of scientists & innovators. 🔬 #WomenInScience #WomenInSTEM

submitted 29 days ago • 58 comments

American colleagues making some very obvious, but unfortunately necessary, comments about the importance of foreign aid. Need to open the link in YouTube to watch it. youtu.be/PqUESHfuO_8?...

submitted 31 days ago • 0 comments

pubmed.ncbi.nlm.nih.gov/39773433/

submitted 45 days ago • 0 comments

📣Published TODAY 📖 It means so much to me to share our paper on #PalliativeCare & #EoLC for people with pleural #Mesothelioma 🫁 in @palliativemedj.bsky.social Thank you to @mesouk.bsky.social for funding this research Please share 🔁 journals.sagepub.com/doi/10.1177/...

submitted 85 days ago • 4 comments

See attached for a system for labelling medically inaccurate posts (e.g. vaccine misinformation)

submitted 32 days ago • 0 comments

The entire archive of CDC datasets can be found here. HUGE shoutout to data archivists- this work is important 👏🙌🏻 archive.org/details/2025...

submitted 39 days ago • 232 comments

Absolutely; attached review is an excellent summary covering lots of B12 misconceptions, e.g "Measuring..serum..B12..is neither helpful nor indicated in..monitoring clinical improvement, (nor for) titration of injection frequency" This is the mistake I see the most www.bmj.com/content/383/...

submitted 40 days ago • 0 comments

Lack of nurse representation on new palliative care commission A campaign has highlighted the lack of nurse expertise on a new commission looking into palliative and end-of-life care across the UK. #endoflifecare #nursing #policy #palliativecare #nurses #nhs www.nursingtimes.net/end-of-life-...

submitted 44 days ago • 1 comment

EMA now on Bluesky

submitted 44 days ago • 0 comments

Hey, nice to meet you! We’re the European Medicines Agency or simply EMA, and we make sure medicines in Europe are safe and effective. We talk about new medicines in the EU, latest health advancements, public and animal health news and much more. Follow us #health www.youtube.com/watch?v=UJl-...

submitted 47 days ago • 149 comments

"Data from the DWP reveals that 1 in 5 people given 6 months to live went on to live over 3 years.." Can we accept a reality where these people would miss 3 years with loved ones due to our inherent poor ability to prognosticate? #assisteddying

submitted 50 days ago • 1 comment

I have once again encountered this exact situation in real life. XKCD is far too prescient. xkcd.com/2501/ 🧪

submitted 50 days ago • 8 comments

Looking forward to seeing everyone there

submitted 50 days ago • 0 comments

I've been doing inpatient infectious disease consults all week. For what it's worth every single patient I've seen with influenza did not get their flu shot this season. The youngest has been a healthy 29yo and oldest in their 80s. Flu vaccines keep people out of hospital. Please get your shot.

submitted 53 days ago • 14 comments

Next to fluids, IV diuretics are some of the most commonly mis-prescribed medications in acute medicine 💉🩸 Let's unpack 5 common diuretic prescribing mistakes, and how to correct these 🧵 #emimcc

submitted 54 days ago • 2 comments

Xanomeline, a new class of antipsychotic, acts via muscarinic receptor agonism (i.e. "opposite of scopolamine", so nausea is a prominent adverse effect) It doesn't block D2 receptors (so far fewer extrapyramidal effects)[authors of this SysRv declare no confl. of interest] doi.org/10.1016/j.jp...

submitted 53 days ago • 1 comment

"This study identifies..... absolute increases in risk of harms among patients with stable long-term prescription benzodiazepine treatment who....discontinue relative to continuing treatment.....Policy broadly promoting benzodiazepine discontinuation may have unintended risks"

submitted 55 days ago • 0 comments

Guanfacine is an alpha-2 adrenoceptor agonist (relatively a2A selective) Like tizanidine, it is oral only and causes less hypotension than clonidine and dexmedetomidine This review examines potential use in delirium; they found case reports/open label series, but no RCTs doi.org/10.1016/j.cc...

submitted 58 days ago • 1 comment

Good piece on issues and possible solutions with accessing end-of-life medicines in the community, and pleased to be able to contribute.. pharmaceutical-journal.com/article/feat...

submitted 59 days ago • 0 comments

Lower bed numbers can only work if we do more in the community; yet we've seen yr on yr reduction in the resourcing of community health and social care; zero reform of the systems needed (quicker access to diagnostics and to drugs); and an erosion of the experienced clinicians needed to do it

submitted 60 days ago • 1 comment

Join us for our free evening webinar series, delivered from Helen & Douglas House

submitted 61 days ago • 0 comments

“It’s so blindingly - excuse my language - bleedin’ obvious that in an intelligent, affluent, civilised society we get this done.” Sir Andrew Dilnot tearing strips off the government yesterday for deferring addressing the crisis in social care until 2028. (1/3) www.theguardian.com/society/2025...

submitted 62 days ago • 12 comments

In this study (n=46; 32 completed the study), lidocaine IVI administered over 1 hour predicted subsequent response to oxcarbazepine [see graph next]. This is perhaps unsurprising given that both are believed to act predominantly via sodium channel blockade. medscimonit.com/abstract/ful...

submitted 62 days ago • 1 comment

Nerve pain starts with ectopic foci on damaged nerves due to over-expression of sodium channels (hence use of carbamazepine, lacosamide etc) But other channels are also implicated including HCN channels, blocked by ivabradine, hence exploring possible analgesic properties doi.org/10.1016/j.ne...

submitted 64 days ago • 1 comment