pezhouh.bsky.social
Pathologist. Mom. Yogi. Associate Professor of Pathology at University of California San Diego. #GIpath #Liverpath #pathology#mindfulness #yogi #pathology
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worst human ever!
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This is a microcystic/reticular schwannoma. They have NONO::TFE3 fusions. Karen Fritchie (CCF) wrote up a nice series. pubmed.ncbi.nlm.nih.gov/37468653/
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Why “not quite right”? It’s got thick, hyalinized vessels and some compact area with palisading. The cells have gorgeous processes, creating a strikingly “reticular” appearance. And it is TFE3-positive.
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By IHC it is diffusely CD34-pos, shows strong nuclear WT1, and contains scattered desmin-pos cells. This is a superficial CD34-positive fibroblastic tumor. Very low grade tumor, often with PRDM10 fusions. Jody Carter, now in Edmonton, wrote this paper. pubmed.ncbi.nlm.nih.gov/23887307/