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rgsheld.bsky.social
Neuroscientist / synaptic physiologist interested in protein topography and cellular signal transduction. Ephys in the past, cryoET now, mouse genetics forever. https://scholar.google.com/citations?hl=en&user=ESpBK1AAAAAJ
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Soapbox: acknowledging that the establishment of pax americana is often a morally complicated legacy does not require you to say there is no "wrong side of history." Nuance =/= nihilism and whataboutism is designed to paralyze you into believing you can never act in a principled manner.

submitted 1 day ago • 0 comments

As flying in the US gets increasingly dicey, we will have to fall back on our rail system in order to travel safely. *whispered sidebar* oh I see...

submitted 3 days ago • 0 comments

#NIHFundedDiscovery How do cells avoid the "kiss of death"? Gap junctions share life-saving signals—but under stress, they shut down to prevent spreading cytotoxic damage. #CryoEM reveals the molecular switches behind this process! www.biorxiv.org/content/10.1... www.biorxiv.org/content/10.1...

submitted 7 days ago • 2 comments

Somewhere between this Derek Lowe quote and the Kendrick halftime show, you will find my current vibe

submitted 7 days ago • 0 comments

Over on LinkedIn, the head of the Executive Secretariat of the NIH -- a central part of NIH leadership 🧪🩺-- resigned with a lettter worth reading www.linkedin.com/posts/nathan...

submitted 8 days ago • 45 comments

Window shopping for Scientifica rigs like pressing my nose against a Ferrari dealership

submitted 9 days ago • 0 comments

Going to patch for the first time since 2018 (🤯). How long do we think it takes to get a decent trace? Like riding a bike, I'm sure 😬

submitted 10 days ago • 0 comments

Federal employees (even probationary) have rights and should immediately appeal if they are fired. www.mspb.gov

submitted 14 days ago • 0 comments

My small selfish bit of rage – insignificant compared to the existential threats to US science – is that the work of almost half my life is going really well and taking off into new directions and I would love to be happy and optimistic about that.

submitted 14 days ago • 1 comment

Life is offering up an abundance of lemons, therefore:

submitted 16 days ago • 0 comments

Excited to share our new preprint "Dynamic nanoscale architecture of synaptic vesicle fusion in mouse hippocampal neurons" www.biorxiv.org/content/10.1... We combine optogenetic stimulation of neurons with in situ cryo-ET to characterize membrane dynamics during synaptic vesicle fusion ❄️🔬⏱️

submitted 16 days ago • 6 comments

No tariff could be conceived to damage a Canadian more

submitted 19 days ago • 0 comments

This is the end of science as we know it if it stands—15% IDCs for all NIH Grants. grants.nih.gov/grants/guide...

submitted 21 days ago • 6 comments

Getting ready to fly back to the states after a great conference:

submitted 21 days ago • 1 comment

Hey #teamtomo, if you often find yourself using the excellent membrain-seg from @lorenzlamm.bsky.social et al., you might find my napari plugin "napari-segselect" useful. Let's say your tomogram contains the edges of two bacterial cells, each with a membrane and cell wall:

submitted 23 days ago • 2 comments

So nobody wants to fly to Frankfurt on a Monday in February, I guess...

submitted 25 days ago • 1 comment

Does anyone have a good entry point into the literature on RNA aptamers? Sifting through lots of papers at the moment trying to work my way back.

submitted 30 days ago • 1 comment

We have an exciting opportunity for a new independent group leader with an interest in structural/molecular biology and machine learning to join our Division of Structural Studies at the @mrclmb.bsky.social! 🥳 Re-posts appreciated. www.nature.com/naturecareer...

submitted 33 days ago • 1 comment

Thinking a lot about "what ifs" inspired mostly by current chaos. Unearthed my biggest alternative life:

submitted 36 days ago • 1 comment

Attempting the ultimate leap of faith: connecting through Chicago in January.

submitted 39 days ago • 0 comments

Our newest paper is out! Congratulations to lead author @elisafrankel.bsky.social! www.sciencedirect.com/science/arti... #Neuroscience #WormFeed #NeuroPapers #Celegans

submitted 44 days ago • 1 comment

Paging @drosophilosophy.bsky.social

submitted 44 days ago • 1 comment

Spiny night for #FluorescenceFriday! Trying some out of left field ways to visualize busy samples. Actin (rainbow depth-color coded) and microtubules (gray) along mature dendrites. projection of a 3D-SIM stack with some undisclosed tricks

submitted 49 days ago • 3 comments

For all #cryoEM practitioners in #NYC, @fitzpatricklab.bsky.social is excited to host Prof. Wolfgang Baumeister next Thursday with attendance open to all and no registration necessary. Hope to see you there!

submitted 50 days ago • 1 comment

It's funny to get older in science and increasingly have the experience of "name et al." becoming "oh hey friend et al."

submitted 56 days ago • 0 comments

My new years resolution is to realize a longstanding goal of achieving one of the two ideal body types:

submitted 59 days ago • 0 comments

We all unwind differently after a long day, I guess

submitted 70 days ago • 0 comments

There is a postdoctoral position available in cryoET and FIB/SEM of Parkinson's disease available in at the Franklin! See details here: opportunities.rfi.ac.uk/vacancy/post... This work is in collaboration with our partners at MSD and their London Discovery Centre. Please share!

submitted 70 days ago • 1 comment

FIB perspective lamellae = Rothko paintings

submitted 73 days ago • 1 comment

SPACEtomo v1.2 is online! github.com/eisfabian/SP... - Improved GUIs for lamella detection, target selection and CLEM registration make it the best target selection workflow for PACEtomo on any kind of lamella sample. - Easier installation and configuration Any feedback is much appreciated! :)

submitted 74 days ago • 0 comments

What happens if child vaccination programs are ended? In 2018, the Samoan govt suspended the measles vaccination program after a medical error Vax rates for one-year-olds declined to 31% A 2019 outbreak infected 5700+ & 83 died, mostly young children We can prevent this from happening again

submitted 77 days ago • 3 comments

STILL TIME TO SIGN UP!!!

submitted 78 days ago • 1 comment

Mary’s long, luxurious baths have drawn so much attention that an envious elephant at the Berlin Zoo has figured out how to shut the water off on her supersoaking rival—a type of sabotage rarely seen among animals. Learn more: scim.ag/49C1s3S

submitted 78 days ago • 2 comments

I joined 75+ @nobelprize.bsky.social laureates urging US Senators to oppose RFK Jr.'s confirmation as DHHS Secretary. If you’re in a state with GOP senators, PLEASE reach out to them! I’d deeply appreciate it if you amplified this post! 🙏 www.nytimes.com/2024/12/09/h...

submitted 81 days ago • 15 comments

RFJ Jr.'s anti-vaccination campaigns have killed children: www.theguardian.com/world/2024/n... They will likely do so again if he is confirmed. Regardless of what state you are in, hearing from the electorate is the only way senators know which fights to pick and which they can't afford not to.

submitted 81 days ago • 0 comments

Excited to share our new work! We shed light on the sociology of virus-induced condensates supporting reovirus assembly and replication. Visualized using #CryoET #CryoEM and #FIBmilling www.nature.com/articles/s41... Great collab w/ @xianxia13 @zhou_lab Xiaoyu Liu @gonenlab

submitted 81 days ago • 1 comment

This was after she dropped a toy on my face.

submitted 82 days ago • 9 comments