rgsheld.bsky.social
Neuroscientist / synaptic physiologist interested in protein topography and cellular signal transduction. Ephys in the past, cryoET now, mouse genetics forever.
https://scholar.google.com/citations?hl=en&user=ESpBK1AAAAAJ
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388 following
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www.sfchronicle.com/bayarea/arti...
Tldr a bunch of diesel spilled on road this morning
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I had one over Jan 20-22. Very gross to re-emerge to the news post inauguration
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There must be, at max, 50 people on this flight. 200+ empty seats
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Incredible, thanks!
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Gene Machine by Venki Ramakrishnan is an interesting read.
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Other fun things include the "Jennifer Aniston neuron"
en.m.wikipedia.org/wiki/Grandmo...
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Neuroscience covers lots of scales and we're all biased toward our preferred one. Lots of cognitive and systems level work relies on correlating neural activity to behavioral output. The huge power of optogenetics is giving some experimental control over activity to make assertions on causality
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I will tap out on the details here as I am very much not a systems/cognitive neuroscientist. There are definitely different types though (episodic, semantic...others...) and there is not just a single brain region "in charge" of all types of memory
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A good peer review comment 😬. Generally, you need some way to make expression specific to the cells you are interested in with genetic tricks. Cell type specific promoters, injecting viral expression vectors to specific areas, etc. Even then "light > activity" can be a sledgehammer approach.
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Not sure what level of detail you need, but the general idea is that the protein channelrhodopsin converts light to electrical activity. Electrical activity is how neurons in the brain convey information, so it lets you change their activity experimentally. In this case making a "false memory"
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Lots of work from Steve Ramirez at BU (theramirezgroup.org ). This paper is old now but still very cool:
pubmed.ncbi.nlm.nih.gov/23888038/
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Oh I love that!
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Great speaker line-up!