rkoszul.bsky.social
#3Dgenome, #3R, #chromatin, #synbio, #microbiome... Opinions are my own.
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www.washingtonpost.com/education/20...
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Maybe they should lock him inside so he can count the gold and reopen the vault in 2075.
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🖐️ thanks!
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Entre autre :
theconversation.com/is-it-time-t...
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See also accompanying perspective by @gfudenberg.bsky.social and @vram142.bsky.social :
Relating DNA sequence, organization, and function | Science www.science.org/doi/10.1126/...
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All these results and much more can be found in our paper, a massive work led by @leameneu.bsky.social, @christophechapard.bsky.social, and Jacques Serizay who generated all the beautiful analyses. Thanks to all the contributors, esp. @chromozz.bsky.social and Alex Westbrook for the deep-learning!
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This result suggests that simple sequence-dependent features could have contributed to the emergence of bipartite compartmentalization of genomes during evolution, either by sequestering inactive genetic material or by facilitating the functional integration of active sequences.
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Deep learning models (@chromozz.bsky.social) trained only on yeast chromosomes predict nucleosome positioning, RNA Poll II and cohesin tracks along foreign DNA, based on the sequence alone. This implies that the behavior of any DNA in a host cell follows deterministic sequence-based rules.
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Dispersed over several chromosomes, this inactive compartment is maintained until mitosis when cohesins compact all chromosomes similarly.
Reducing transcription eliminates compartmentalization, with all yeast chromosomes now resembling the bacterial chromosome...
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Sequences close to the yeast GC are highly transcribed, somehow following the orientation of prokaryotic genes, and mix with yeast chromosomes.
In contrast, a rich AT bacterial genome is not transcribed and forms a globule at the nuclear periphery, independently of SIR heterochromatin formation...
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Using MNAse, ChIP, ATAC, CRAC and RNA-seq, Hi-C and imaging, we characterized the composition, activity and folding of bacterial genomes of varying sequence composition introduced as supernumerary chromosomes into budding yeast. Depending on their GC%, their fate was surprisingly different.
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Innovation dans la fabrique des sacs a main et des valises, hein.
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C'est pas là ?
www.cnrs.fr/fr/actualite...
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Toutafé
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Toutes les sections n'en ont pas d'ailleurs. Pour avoir siégé dans les deux types je confirme que le clarté de l'info dans le dossier est primordiale dans un cas comme dans l'autre...
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Et c'est pas faute de le répéter...
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On peut lire "les mains du miracle" de Kessel, d'ailleurs pour la version tres romancee de Kersten... mais pour les révélations sur le fait que les bus ont d'abord servi à déplacer des prisonniers vers d'autres camps pour regrouper des "nordiques" sur un site il faut lire les historiens...
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Pour relancer la discussion...
www.20minutes.fr/societe/4002...
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C'est aussi intéressant en demandant de critiquer certains aspects entre les lignes... c'est pas subtil et je me demande si ça reflète des vacheries balancées dans des vrais rapports jamais vus dans mon domaine !
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🖐️ ? thanks
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La Mouette à l'Odéon
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A step that often follows awareness of strains, individuals and genetic redundancy :-)
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And that's before Gaetz even started.
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Very nice Axel ! Congratulations !
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Et les CID ? Ça reste en place ?