sebastianbaatz.bsky.social
Nephrology, ERKNet, Nephrogenetic, ADPKD, Leipzig UKL
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380 followers
170 following
Regular Contributor
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17/
I'm very curious how others (e.g., @kidney_boy @Nephro_Sparks) think through this. It's hard to find articles directly addressing this exact question...
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There is also quite good data on whether someone metabolizes quickly or slowly after NTx.
pmc.ncbi.nlm.nih.gov/articles/PMC...
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4) Ileal conduit. Not that common, but I had 2 consults for them so
👉When urine ⬆️ in NH4Cl empties into a section of the ileum, NH4 is reabsorbed through the Na-H antiporter of the ileum. Bile acid malabsorption may also cause diarrhea.
👉In sigmoid diversion, Cl is absorbed in exchange for HCO3.
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youtu.be/d_ap7EPap_Q?... @andrewmallett8.bsky.social @ksusztak.bsky.social @kdigo.bsky.social
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5/5 They plan on doing a multi-centre trial, #EMPASTONE
ctv.veeva.com/study/trial-...
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So in summary
🔎when considering Hz-glomerulonephritis look for multiple autoantibodies, high ANCA titers, vasculitis and lupus overlap
📆timing occurs after 3-5 years of Hz use, higher doses = higher risk
🧬genetics may increase risk
🏥IS may help, but about 1/3 stay on dialysis
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On that topic you may enjoy this: youtu.be/GqRk5g93eLc?...
#NephGR - we are participating in a trial to start soon!