tatianadimitriu.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

Thanks to the more than 1100 members of the scientific community who have signed the letter to insist that the Royal Society remains true to values that we all hold dear but that Musk FRS has ridden roughshod over. Please keep signing & sharing. docs.google.com/forms/d/e/1F...

submitted 11 days ago • 6 comments

It has been brought to my attention that my article has been censored to exclude certain terms: asm.org/Articles/202... web.archive.org/web/20250114... #MicroSky

submitted 19 days ago • 43 comments

New preprint from our Lesterlin Lab! Yannick Baffert and @nfrk92.bsky.social, in collaboration with @macerwan.bsky.social and @val-meve.bsky.social, shed light on the molecular mechanisms driving pOXA-48 plasmid maintenance and transfer. We reveal novel TA system, regulators, and T4SS components!

submitted 30 days ago • 2 comments

🚨 New preprint! We know that plasmids are associated with very variable fitness costs in their different bacterial hosts. But, what is the contribution of each of the plasmid-genes in these host-specific effects? Study led by @jorgesastred.bsky.social, @sanmillan.bsky.social and myself! 1/14

submitted 30 days ago • 4 comments

New pre-print!!! What types of genes end up on plasmids and why? The take home message of this paper is that beneficial genes move from plasmids to chromosome, causing the ecological value of plasmids to decay over time. www.biorxiv.org/content/10.1...

submitted 30 days ago • 5 comments

I hope @royalsociety.org is taking notes

submitted 34 days ago • 4 comments

This paper has been a long time coming: We looked at the genomes of historical bacterial samples over a century to look for trends of antibiotic resistance genes, finding multiple instances of them in infections before the age of antibiotics, but an increase in both frequency and mobility after

submitted 37 days ago • 11 comments

Interested in the plasmidverse? Then, don't think twice and join the International Society for Plasmid Biology Virtual Seminars Series. 👇

submitted 39 days ago • 1 comment

📣Our latest paper is out now in mSystems: Not quite as it may seem - investigating #plasmid diversity and evolution in #Klebsiella pneumoniae at a single institution over time. A short thread 🧵 @zaminiqbal.bsky.social

submitted 40 days ago • 2 comments

🚨PhD studentship opportunity! Bacteria protect themselves with a huge arsenal of defences, but does this affect how they gain new traits on plasmids? 🧫🦠💫 Apply for a funded 4y position with me @livuni-ives.bsky.social, @brockhurstlab.bsky.social @jojofoth.bsky.social & @multidefence.bsky.social ⬇️

submitted 45 days ago • 2 comments

Very happy to see this work published! We unveil a plasmid-chromosome crosstalk by showing that pOXA-48 encodes for a regulator that mediates the transcription of an enterobacterial chromosomal operon, resulting in a growth benefit for the plasmid-carrying bacteria! www.nature.com/articles/s41...

submitted 53 days ago • 2 comments

Here's a project with surprising results: we show the presence of virulent phages across bacterial genome assemblies. Not any phage, and not your typical T1 contaminant, many phages have large genomes and seem to be in a state of persistence/oscillation (?!) between lysogeny and the lytic cycle.

submitted 52 days ago • 4 comments

Certain sublineages of antimicrobial resistant bacteria dominate the surveillance landscape, but what causes them to become resistant? Check out our latest work in Shigella to find out and/or read the thread below www.medrxiv.org/content/10.1101/2024.10.27.24316207v2 1/n

submitted 66 days ago • 4 comments

When a rapid proof-of-concept try for a new experiment works even better than I hoped .. the amplitude of variations is just right to easily test the effect of a number of things :) I almost don't want to leave for the Christmas break so I can play with these now.

submitted 69 days ago • 1 comment

Out in NAR, AntiDefenseFinder & our "systematic" analysis of inhibitors of antiphage systems wt Bondy-Denomy lab led by @ftesson.bsky.social and E. Huiting. Not so "systematic" as very few known, fun stuff on MGE, antidefense islands and cool phages exaptations! academic.oup.com/nar/advance-...

submitted 70 days ago • 1 comment

Is it “winner-takes all” when the simplest living things compete? Check out my fresh publication on phage coexistence in Science and a thread below🧵 www.science.org/doi/10.1126/...

submitted 73 days ago • 5 comments

JOB OPPORTUNITY! I am hiring a postdoc for 18 months to investigate the links between temperature and antibiotic resistance. Ecoevo microbiology, plasmids, and some super fun stats, modelling, and bioinformatics. To starts in Feb 2025. Please share! #exetercec jobs.exeter.ac.uk/hrpr_webrecr...

submitted 74 days ago • 2 comments

Registration now open for the EMBO Workshop: Immune System of Bacteria !!!! www.sisb2025.conferences-pasteur.org/home Joins us in Institut Pasteur, Paris, April 8-10th.

submitted 76 days ago • 1 comment

PhD opportunity in St Andrews on plasmids, antibiotics and defence systems, in collaboration with Helen Alexander in Edinburgh. Funding via BBSRC EastBio, please share & pass on to anyone interested! #microsky🦠🧫🧬 www.findaphd.com/phds/project...

submitted 74 days ago • 0 comments

🚨 New preprint!! How can antibiotic-resistant bacteria increase in abundance in the human gut microbiome, even without antibiotics? 🧐 We show that strain-specific ecological interactions are key to understanding resistance dynamics in microbial communities. 🧵👇 1/5 www.biorxiv.org/content/10.1...

submitted 74 days ago • 2 comments

Des 👩 que vous pensiez peut-être être des 👨 Maud Menten (Michaelis–Menten) Yvonne Barr (virus Epstein-Barr) Marilyn Kozak (séquence de Kozak) Tsuneko Okazaki (Fragments d'Okazaki avec son époux Reiji) Hilde Mangold (Organisateur de Spemann-Mangold) Martha Chase (Expérience de Hershey & Chase)

submitted 75 days ago • 5 comments

ok j'ai pleuré (et c'est pas fini) malgré Macron, malgré Trump, malgré le mélange des genres bizarre, et pas vraiment pour Notre-Dame. Mon père ne se serait pas tenu de fierté s'il avait pu voir ca ... il a eu les frères Capucon comme élèves de musique de chambre quand ils étaient gosses.

submitted 78 days ago • 0 comments

sorry what did I just read

submitted 80 days ago • 1 comment

Funded #PhD project to work with me, @DrSelvaDhan, @andymitch20, @arwynedwards, & @LindaOyama on zoonotic bacterial pathogens and their mobile genetic elements, available through the OneZoo DTP: shorturl.at/DGriT Application deadline: 31st January 2025 Please share!

submitted 82 days ago • 1 comment

Flagellar rotation facilitates the transfer of a bacterial conjugative plasmid in Bacilli www.embopress.org/doi/full/10....

submitted 83 days ago • 0 comments

🆕New in @plosbiology.bsky.social: we show compensatory mutations make plasmids play Rock-Paper-Scissors and turn conjugation into a weapon🛡️💫✂️🦠 w/Rosanna Wright, Jamie Wood, @mbottery.bsky.social, @kmudz.bsky.social, @scottishwormboy.bsky.social, Ellie Harrison & @brockhurstlab.bsky.social #MicroSky

submitted 83 days ago • 3 comments

Happy to see our research on SMC Wadjet published in Molecular Cell. We showed DNA loop extrusion (LE) by a bacterial SMC, confirming LE is conserved across all life forms. Wadjet's LE activity is crucial for recognizing and restricting foreign plasmids, serving as a defense mechanism. 🧬🔬🧪

submitted 83 days ago • 5 comments

Finally, this great effort for the Klebsiella community is out! Congrats to daniela Rothschild & @fnobrega.bsky.social

submitted 83 days ago • 1 comment

Delighted to share this paper out via Virus Evolution: academic.oup.com/ve/advance-a... in which we develop and assess a quantitative method to infer phage and bacterial mutations driving changes in infection phenotypes arising in coevolutionary dynamics. a 🧵 about people (and some science)

submitted 83 days ago • 2 comments

Latest work from the lab, joining past and present students to review an exciting new field. In collaboration with a great friend Hilde Herrema! Well done @danielarothschild.bsky.social, Ruweyda, and Anne.

submitted 84 days ago • 0 comments

Les soupçons d'ingérences dans l'élection roumaine se font sentir. Mais, au-delà de l'ingérence, il y a une question : des influenceurs ont-ils été payés pour faire campagne pour Georgescu en Roumanie ?

submitted 87 days ago • 5 comments

Exciting times! Our latest preprint is now live 🤩! After nearly 16 yrs of running my lab, I truly believe this is one of the most significant contributions we've made. It offers fresh hypotheses about how pandemic Vibrio cholerae spreads globally. Let’s dive in!🧵..1/n www.biorxiv.org/content/10.1...

submitted 90 days ago • 4 comments

Get ready to dance, our paper – Phage DisCo: targeted discovery of bacteriophages by co-culture – has been pre-printed! 🪩 This has been a really fun project to work on with @sianowen.bsky.social, @baym.lol, @nquinoneso.bsky.social, and our two talented undergrads Kesther and Carmen!

submitted 92 days ago • 4 comments

And finally, a recent review we wrote speculating on the evolutionary aspects of MGEs mobilising chromosomal DNA

submitted 97 days ago • 0 comments

Re-sharing our last paper on the effect of restriction-modification systems on conjugative plasmids: doi.org/10.1093/nar/... #MicroSky

submitted 97 days ago • 3 comments

Well I never had near that number of followers on Twitter! I mostly use this for science, with occasional landscapes, short moans about french politics (mostly when I don't find french people around), and photos of my cats because they are objectively the cutest things in the world - proof attached

submitted 97 days ago • 0 comments

Important paper - just imagining the possibilities if bacteria sense phage infection in neighbours

submitted 100 days ago • 2 comments

Hello new phage phollowers! I am shamelessly self-promoting mine and Angus Buckling's relatively new review "Critically evaluating the relative importance of phage in shaping microbial community composition" www.cell.com/trends/micro...

submitted 100 days ago • 8 comments