cashwood.proteaglyco.com
Director of Protea Glycosciences
Accelerating glycoscience research
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Finally, we have Shulei Liu from UQ and the @benschulz.bsky.social lab
describing a Thermal Glycoproteome Profiling approach to understand which #glycotime sites are important for glycoprotein folding and structure.
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Following, we have @maiakelly.bsky.social from Georgia Tech/Protea Glycosciences, presenting the command line version of GlyCombo.
Specifically, how it has been developed from a standalone application to a module as part of an integrated #glycotime bioinformatic workflow.
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Next is Katherine Wongtrakul-Kish from Macquarie University. She is defining the role N-glycosylation plays in masking glycoprotein detection, with a specific example of CD36.
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First up, Nicholas Debono from Griffith University, describing NeuGc in humans.
Since humans lack the ability to make NeuGc, dietary conditions could influence NeuGc abundance.
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I’d rather not spioil #ASMS2026, but Nike is already leaking the next iteration name:
Astral ZoomX Invicible
Wearing these shoes gives you a bonus 5% scan speed
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Finally, we have Gene Hart-Smith presenting his work at APAF, using cross linking to research tau-PSD95 structure, an intrinsically disordered protein.
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A couple of sessions later (low battery), we have @mredwardmoh.bsky.social presenting a multi-glycomics workflow applied to extra cellular vesicles
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Finally, we have Therese Fulloon describing how lipid unsaturation impacts the 3D shape of ionised lipids.
Comparing isomeric lipid CCS values, future opportunities for discrimination have been identified. #ausomics
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Now, we have Hartmut Schlüter describing a novel tissue isolation approach that is gentle, reducing protein/metabolite degradation for subsequent multi-omic interrogation. #ausomics
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Third speaker in this session was @cashwood.proteaglyco.com, giving a sweet talk on glycoprotein characterisation #TeamMassSpec #ausomics
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Next is Christoph Krisp, from Bruker, presenting a single cell proteomics workflow using Cellenion, Evosep (whisper zoom), and Bruker (timsTOF Ultra 2) instruments.
With tmt 9plex (no carrier), it greatly reduces Evotip usage.
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I’m not sure, only tried it a little in lab.
One of the authors, @searleb.bsky.social, will be able to answer your question better.
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Yes, I agree.
Though won’t be a great method if you’re not hitting the AGC target early (based on maximum injection time).
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That’s where I learned about Thermo’s eDR application of a similar approach, metabolomics.
They only use two “boxes” instead of the six you see here.
Optimal number of boxes, box width and m/z centre are likely analyte dependent.
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Hope the conference air con cuts down on the humidity!
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The problems are with the affordances of the technology and how they mislead even sophisticated professionals: these tools work extremely quickly and dispense superficially coherent and confident output. These qualities override skepticism and promote reliance.
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A good embodiment of the Australian spirit when it comes to instrument claims.
Nice twist on the traditional marketing video.
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It's hard to tell because the raw files aren't publicly available yet.
The wording varies in the manuscript but this phrase, "We used a prototype Zeno trap-enabled Sciex QTOF, similar to the ZenoTOF 7600+ system", implies it's different from the 7600+.
But maybe the 8600 has more features to come?
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Count on a visit from me!
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Sounds like vendor-specific improvements.
As someone that uses multiple vendors, I'm not going to have a Sciex-specific workflow and then a workflow for every other vendor.
Not to mention that those workflows are then processed in such different ways, I can't troubleshoot the discrepancies.
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Please find below SCIEX's comment to customers in regards to this. Reads like their support for open-source, free software is not aligned with their long term goals.
As far as I can see, SCIEX do not provide an alternative to Skyline, just mzml conversion.
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Takes some hubris to pull out of supporting open-source research in order to spend more money duplicating the effort, in a way that no one can troubleshoot.
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No idea. The Skyline team are being transparent about this, so hopefully Sciex follows suit and explains their perspective soon.
Otherwise it reflects poorly on Sciex.
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I am indeed assuming that Sciex are being reasonable.
There is the alternative that they’re building a walled, closed-source software ecosystem that is designed to extract as much money from their customers as possible, and Skyline is a roadblock for that plan.
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As long as the code isn't wound back to remove any existing support, they should be okay.
From Sciex's point of view, I can see the challenge in justifying funding software whose Project Leader is a Thermo consultant.
Hopefully both parties can find a middle-ground and resolve this ASAP.