marstonlab.bsky.social
Cell Biologist excited about Chromosomes, Meiosis and Mitosis. Director, Wellcome Discovery Platform for Hidden Cell Biology
18 posts
1,678 followers
1,438 following
Regular Contributor
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A special thanks to the fly expert reviewers for helping us clarify a few points, including the late Scott Hawley, whose review was filled with the enthusiasm and generosity we all knew him for.
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I am very shocked and saddened to hear this news. He made so many important contributions in so many different ways.
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See also related work by @eecutts.bsky.social and thanks to Erin and Luis for a great co-submission experience www.embopress.org/doi/full/10....
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Overall we show that Mad3 acts outside of its checkpoint role to actively direct chromosome segregation.
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We found that Mad3 binds the Stu1 (CLASP) microtubule regulator through its degenerate TOGL1 domain. We showed that Mad3-Stu1 association rescues the segregation of chromosomes that lack crossovers or fail to biorient in meiosis I.
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We discovered that in addition to its well known role in delaying the cell cycle as part of the spindle checkpoint, Mad3, has a separate role in promoting chromosome alignment on the spindle in budding yeast meiosis.
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Thanks! Indeed! 🎄