tuuliel.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

Expanding Perturb-seq-like screens to multicellular systems also increases the complexity of confounding effects. We encountered this when we perturbed all TFs in mosaic embryoid bodies (EBs) and develop a scalable solution by barcoding monoclonal individuals. 🧵 www.biorxiv.org/content/10.1...

submitted 3 days ago • 1 comment

Naiivi juttu. Trumpin hallinnon toimissa on kyse paljon suuremmista ja pimeämmistä voimista kuin henkkoht kostoretkistä tai sekoilusta. Suunniteltu (ks. Project 2025) hyökkäys akatemiaa vastaan on yritys murtaa yksi vapaan demokratian keskeisistä pilareista. www.hs.fi/maailma/art-...

submitted 20 hours ago • 1 comment

Genuinely... quite excited about this. I think I might have to install it just for old skool x new school kicks. (plus - great for controlled cloud environments!)

submitted 1 day ago • 0 comments

Zohran Mamdani is well within striking distance to become the next mayor of NYC 🤩 and first win the primary against Andrew Cuomo, the ~Republican, Trump donor supported serial sexual harasser with a track record of mismanaging NY state.

submitted 1 day ago • 0 comments

SUM-seq out @natmethods.nature.com !  🚀 Ultra-high-throughput Multiplexed snATAC+RNA Used to: ⏳ link temporal macrophage GRNs to immune disease genetics 🩸 map T cell regulatory landscapes 🧬✂️ dissect TF function in hiPSC differentiation via CRISPRi/a screens doi.org/10.1038/s41592-025-02700-8 🧵

submitted 2 days ago • 1 comment

Billionaires are funding Andrew Cuomo because they know he’ll work for them, not you.

submitted 3 days ago • 14 comments

Scientists, I am asking us to do something that goes against our nature: Step away from fine-grained, nuanced arguments. Zoom WAY out. Share the big picture. Don’t soften the seriousness of this moment with “xxx may be ok in xxx circumstances” talk. It’s uncomfortable AND necessary.

submitted 3 days ago • 16 comments

Do you have an interest in B cells and immune-mediated diseases? We generated a multiomics resource of human B cell activation and showed its utility for elucidating disease mechanisms. Check out our manuscript led by @vitoraguiar.bsky.social and Marcella Franco: www.medrxiv.org/content/10.1...

submitted 4 days ago • 0 comments

These times have proved that it is good to have something like Section 16.3 of Finland's Constitution: 'The freedom of science, the arts and higher education is guaranteed'.

submitted 5 days ago • 1 comment

Harvard today, your institution tomorrow. It's all part of the Project 2025 plan to destroy high education in America. All leading US universities depend on federal funding and tuition dollars from international students. They severely curtailed the former. Now they're eliminating the latter.

submitted 6 days ago • 50 comments

“I am writing to inform you that effective immediately, Harvard University’s Student and Exchange Visitor Program certification is revoked,” according to a letter sent to the university by Kristi Noem, the homeland security secretary. A copy of the letter was obtained by The New York Times.

submitted 6 days ago • 1 comment

Recently presented our work on how spatial transcriptomics + genetics can reveal putative causal tissue structures for complex traits. 📄 Preprint: doi.org/10.1101/2025... #spatialbiology #genomics #genetics @lifesciences-ge.bsky.social

submitted 6 days ago • 1 comment

Welcome back from the break! Next up @juliadiumenge.bsky.social from @alloxbio.bsky.social Mapping allosteric sites at scale to develop better drugs

submitted 6 days ago • 0 comments

title of assistant professor's talk: amino acid metabolism of effector T cells in LCMV infection title of senior full professor's talk: Why do cells eat?

submitted 8 days ago • 7 comments

Are you based in the U.S. 🇺🇸 or Canada 🇨🇦 and thinking of doing research in Europe? ERC grants offer up to €4.5 million to support groundbreaking, investigator-driven frontier research in all fields. Watch the dedicated info session for researchers in your region👉 youtu.be/92QYink1Lik #ChooseEurope

submitted 9 days ago • 1 comment

Postdoc opportunity! At National Genomics Infrastructure in Uppsala we're looking for a postdoc in genomics R&D. Cutting-edge methods dev in an excellent, international environment at the junction between academia and infrastructure. Deadline May 23! www.uu.se/en/about-uu/...

submitted 8 days ago • 1 comment

Farewell to friend & labmate Dr. @oahmed.bsky.social whom I hooded today! He's moving on to exciting new things in his postdoc at @nygenome.org with @nevillesanjana.bsky.social & @tuuliel.bsky.social. You are already much missed, Omar! 🫡 ❤️ 🎓

submitted 9 days ago • 1 comment

“The results show that, with current trends and policies, the situation is projected to worsen to 2050 for all planetary boundaries, except for ozone depletion.” www.nature.com/articles/s41...

submitted 13 days ago • 0 comments

Free in-person registration is open for #MLCB2025! Sept 10-11 at @nygenome.org and online at youtube.com/@mlcbconf. Paper/abstract deadline is June 1, more deets including our fantastic invited speaker lineup at mlcb.org! Please RP.

submitted 14 days ago • 0 comments

Keynote talk from Steven McCarroll from last weeks Biology of Genomes conf. My favorite talk of the whole meeting! #bog25 youtu.be/BCRAlmFv7ag?...

submitted 14 days ago • 3 comments

Check out our scPrediXcan paper www.cell.com/cell-genomic... Led by the talented @Charles_Zhou12 and supervised by @MengjieChen6 and me, with thanks to many contributors. scPrediXcan integrates deep learning and single cell expression data into a powerful cell type specific TWAS framework.

submitted 14 days ago • 0 comments

The human pangenome continues to grow and improve! Release 2 is here! Click through for the details, but this is a pretty amazing dataset including not just the phased assemblies, but PacBio HiFi, ONT Ultralong, Dovetail/Illumina Hi-C, PacBio Kinnex, and Illumina WGS for all samples

submitted 16 days ago • 0 comments

Velkabluffi on paljastettu. Orpon hallituksen sopeutuksen tavoitteena oli lähinnä ajaa hyvinvointivaltiota alas ja paisuttaa rikkaiden lompakkoa, eikä vahvistaa julkista taloutta. Sopeutus kuihtuu käytännössä kokonaan pois uusimmassa julkisen talouden suunnitelmassa. @jussisysta.bsky.social

submitted 15 days ago • 2 comments

Great to see Canada joining the nation-wide efforts in utilising Genomics to revolutionize healthcare.

submitted 18 days ago • 2 comments

Are you a US-based academic that has prior ties to Sweden? Are you also 7-12 years from your PhD? If so, the Foundation for Strategic Research is providing funds of up to $1.5 mil (15m SEK) to bring you back to Sweden! Application deadline Sep 23. strategiska.se/pressmeddela...

submitted 19 days ago • 2 comments

What's happening with these grants is much more complicated and mostly unknown. None of the NIH have been officially cancelled. The NIH was just ordered to stop paying. They got the Unis to enforce silence on their own campuses because they thought they were "negotiating" and cld get the funds back.

submitted 22 days ago • 38 comments

Kicking off Biology of Genomes with opening remarks by @tuuliel.bsky.social! @cshlnews.bsky.social #bog25

submitted 22 days ago • 0 comments

Our new contribution to the quest to find causal GWAS genes! Sam Ghatan from my lab at @nygenome.org led a systematic comparison of eQTLs and CRISPRi+scRNA-seq screens. TL;DR: they provide highly complementary insights, with ortogonal pros and cons. 🧵👇 www.biorxiv.org/content/10.1...

submitted 22 days ago • 1 comment

Two things that are true at the same time: 1. The massive cuts to science funding in the US is a terrible blow that can't be patched by efforts elsewhere. 2. It's great that the EU and many individuals countries are stepping up; it helps science and many US scientists willing/able to relocate.

submitted 22 days ago • 1 comment

Our new work testing nicotine, alcohol, and caffeine exposure across many cell types at once, including their modulation of eQTLs. Take a look!

submitted 23 days ago • 0 comments