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rodrahimi.bsky.social
Physician-Scientist at Massachusetts General Hospital. Posting about biology (mostly immunology) and medicine https://www.rahimi-lab.com
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With an Ro of 12-18, a mortality rate of about 1-2/10,000 and an MMR vaccination rate in this area of Texas at 82% we should expect to see this expand to many 1000 cases quickly and, unfortunately, potential deaths.

Share beyond your scientific networks. *no* new science is being funded (or assessed for funding) Not fewer Not only on select topics None. Zero.

Summary of the infuriating blockade of US medical research “This crisis...has already consumed one funding cycle” Carole LaBonne said. “But if this block to publishing in the register continues on much longer, it’s going to swallow two funding cycles, and that will put many labs out of business.”🧪⚕️

The conclusion of the initial NIH Indirect Cost court case this morning... Great thread outlining the arguments by the plaintiffs and the lawyers for the NIH (who are advocating for the 15% cap on behalf of the Trump administration).

Here are some data documenting the funding "pause" pulled from NIH Reporter. Current results (FY25) (Red) are compared with results from FY21 (first year of Biden Administration) and FY24. Note that data from Reporter lag behind release of NoAs by ~1 week. I will be tracking this going forward.

"A freeze on meetings of expert panels that peer review grant proposals at the NIH is kicking in this week ... Trump barred NIH from posting new Federal Register notices, which means any study section not advertised before then cannot take place." #medsky 🧪 www.science.org/content/arti...

And then there are the ancillary consequences - a constrained pipeline of new talent, and much of the best talent diverted to other professions and away from health research and public service where we really need great minds who are motivated to serve the common good.

RFK Jr. thinks that a clinical trial should be done for the entire childhood vaccine schedule. Here’s why that will never happen. 1. You can’t do a randomized trial of something that we already know is safe and effective. There would have to be a placebo group that didn’t get vaxxed. Unethical.

It’s been FIVE DAYS since this man voted to confirm an antivaccine activist to run HHS

Excited to share this new work led by postdoc Brendan Floyd, deep mapping of cell-surface protein interactomes of T and B cells reveals maverick mitochondrial proteins and immune modulatory complexes. www.biorxiv.org/content/10.1...

Join us! Science Homecoming helps scientists reconnect with communities by writing about the importance of science funding in their hometown newspapers. We’ve mapped every small newspaper in the U.S. and provide resources to get you started. Help science get back home 🧪🔬🧬 🏠 sciencehomecoming.com

Is someone going to tell them that viral infections play an important role in the development of many chronic conditions, including asthma, autoimmunity, and cancer? 🧪🩺

My colleagues and I have a piece out today in NYT: www.nytimes.com/2025/02/18/o...

Lung CD4+ resident memory T cells use airway secretory cells to stimulate and regulate onset of allergic airway neutrophilic disease @cp-cellreports.bsky.social www.cell.com/cell-reports... @anukulshenoy.bsky.social

NEW: NSF confirmed that they fired 168 employees today, out of their staff of ~1,500 feds. This includes some people who'd finished their 1-year probationary periods, which were extended to 2-years last month without explanation. More to come.

1/ I am seeing a lot of comments on the slashing of NIH support along the lines of “universities should just spend their huge endowments.” I’m the last person to cheer on the institutional stratification rising endowments have contributed to. But let me explain why this is not a solution.

Cool paper from the Davis lab using human tonsil organoids to study CD4 and CD8 Tregs. Even though subjects with autoimmunity were excluded, organoids derived from female donors had higher autoreactivity, providing an ex vivo system to study sex differences in response to self antigens. #ImmunoSky 🧪

“Not only is this effort not accomplishing the task of weeding out inefficiency, but… It's like cutting off your arm to lose weight," said Linda Bilmes, a government efficiency expert with the Harvard Kennedy School.

“legislators must exercise their constitutional responsibilities to oppose unqualified candidates for important federal positions, constrain damaging actions by the executive branch and give science agencies the resources needed…This is not a fight that our country can afford to lose.” 🧪🩺

Quite the flu season we're having. Here are some thoughts. I finish up by wondering why we'd reduce CDC workforce at a time like this -- just unfathomably short-sighted. blogs.jwatch.org/hiv-id-obser...

Good news. Fortunately, it is approved by a federal dept. RFK Jr. doesn't oversee (USDA). Call me pessimistic, but how long until this gets attacked with the usual antivax talking points by people with sig. platforms? "Toxins," human health impacts, etc., etc. 🙄🛟🧪😷 idsky medsky

It is really short-sighted and stupid to be gutting public health and outbreak surveillance capacity right now: - H5N1 nationwide - uncontrolled - TB in Kansas - largest U.S outbreak - Measles in Texas - Expanding - Seasonal flu - Worst in 15 years - Pertussis - outbreaks in multiple states.

In 2015, Newt Gingrich published an op-ed in the New York Times urging that the budget of the National Institutes of Health be doubled. 1/x www.nytimes.com/2015/04/22/o...

Marco Rubio wrote these words on World AIDS Day 2017: www.foxnews.com/opinion/sen-... How does a man go from being a very staunch defender of PEPFAR to being the guy who gleefully blows PEPFAR up & nonchalantly watches people being denied their HIV medicines & transmission rates spike?

Our department received a continuing NOA today including the correct (negotiated) indirect rate. The funding blockade at the NIH appears to be partially relieved for now.

KLF2 maintains lineage fidelity and suppresses CD8 T cell exhaustion during acute LCMV infection www.science.org/doi/10.1126/... @science.org @nikjoshilabyale.bsky.social

Come join our faculty! We’re hiring.

Protect this law at all costs ! www.nbcnews.com/politics/don...

YES!!!!!!!! NIH admits funding freeze is illegal, will resume issuing grants popular.info/p/breaking-n...

Biopharma companies and CEOs are keeping their heads down at their own peril. They should speak up about what’s happening to the NIH and other science agencies before it’s too late. Silence gives consent. And no one should consent to this.

'Bob’s true test of a perfectly structured presentation was that the speaker should be able to ditch the PowerPoint slides and successfully deliver the same message using only the blackboard (...) most talks would indeed be better when boiled down to the bare basics: chalk board, presenter, ideas.'

One of the great stories in the history of medicine. For those interested, highly recommend the book “The Discovery of Insulin” by Michael Bliss 🧪🩺

I'm happy to have moved over to Bluesky - now how many of my #Medsky #Pulmsky friends are over here?

Good historical perspective and great argument from Mary Sue Coleman on indirects: www.insidehighered.com/opinion/view...

There are enough GOP senators opposed to the cuts to NIH indirects to stop them, but they need to act. Keep writing and calling your representatives 🧪⚕️

A great way to push back would be to vote against RFKJ… which is the right thing to do for public health anyway

Just got the dreaded email. University of Iowa is halting all NIH grant submissions. Losing a generation of scientists here will send the state backwards. What a travesty.

Lawsuit filed by state Attorneys General with Massachusetts in the lead asking for declaratory and injunctive relief. coag.gov/app/uploads/...

“Our mission is to save lives and alleviate suffering,” she said. “Not having the opportunity to contribute to that, and have it be taken away overnight, arbitrarily, without notice or reason, being called a criminal or radical lunatic, has just been deeply heartbreaking.”

F99/R00 AND K99/R00 DIVERSITY AWARD APPLICANTS If you have applied for a F99/R00 or K99/R00 Diversity award and the study section for review is not listed on your eRA Commons page, please reach out to me. DM me, email [email protected], Signal jeremymberg.78 THANK YOU

Another assault on US competitiveness at a time when biomedicine is roaring with innovation, an own-goal in a high-stakes international tournament. Of course the real losers are American people needing medicines and cures. www.washingtonpost.com/health/2025/...

My latest column just appeared in Science, entitled "Free speech, fact-checking, and the right to accurate information”. (www.science.org/doi/10.1126/...) I use one of President Trump’s first executive orders to unpack the terrain between misinformation and claims to free speech 1/n

AND IT’S ILLEGAL FOLKS: “None of the funds appropriated in this title may be used to modify or implement any change to the indirect cost rates applied to grants & contracts funded by the NIH w/o the prior approval of the Committees on Appropriations of the House of Representatives & the Senate.” 1/

On changes to #NIH indirect rates, there is a law in place that prohibits NIH from making such changes without the approval of Congress. See Division D, Title II Section 224 of The Further Consolidated Appropriations Act, 2024 (Public Law No: 118-47) grants.nih.gov/grants/guide...

"Pursuant to this Supplemental Guidance, there will be a standard indirect rate of 15% across all NIH grants for indirect costs in lieu of a separately negotiated rate for indirect costs in every grant." grants.nih.gov/grants/guide...

My student's diversity F31 has been pulled from study section even though it's the SAME APPLICATION as regular F31s, normally reviewed together in the same panel. Throwing out all the applications from URMs while the ones from white/privileged students get to be reviewed is blatant discrimination.

‪Science Seminar with Prof. Luke O'Neill on February 13th at 1pm on 'How Mitochondria Control Cytokines'. Please register at www.eventbrite.co.uk/e/cardiff-un... @lukeanthonyoneill.bsky.social

SCOOP: Cats that became infected with bird flu might have spread the virus to humans in the same household and vice versa, according to data that briefly appeared online in a report from the Centers for Disease Control and Prevention but then abruptly vanished. www.nytimes.com/2025/02/06/h...