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aheadofthenerve.bsky.social
BRAIN K99/R00. HPC experim & comp systems neuro. Ephys4life. Postdoc @NUFeinbergMed w @Disterhoftlab & @SaraASolla. PhD @MITbiology w/ Matt Wilson 🔬🧠🐀🌈
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Prolific Poster

The Atlantic story on the situation at NIH is sobering. We are so screwed. www.theatlantic.com/health/archi...

No one had died of measles in America for ten years, until yesterday. That 2015 death in WA was preceded by a 12y period of no US deaths. www.nbcnews.com/health/healt... HHS Secretary RFK Jr. says it’s “not unusual.” apnews.com/article/meas... It is unusual. www.cdc.gov/measles/data...

Nucleus accumbens dopamine encodes the trace period during appetitive Pavlovian conditioning I will also be curious to know what is the time course of behavior during the trace delay www.biorxiv.org/content/10.1...

New preprint from our lab on memory incorporation into dreams! 🧠 💭 💤 Palmieri et al. Incorporation of complex narratives into dreaming doi.org/10.1101/2025...

📢Abstract submissions is 16th March AOE for the Annual Conference on the Mathematics of Neuroscience and AI (May 27-30th; National Opera Theatre, Split, Croatia) A truly outstanding line-up of keynotes, session chairs, and invited speakers. We'd love you to come along too! www.neuromonster.org

Curious about the history of the manifold/trajectory view of neural activity. My own first exposure was Gilles Laurent's chapter in "21 Problems in Systems Neuroscience", where he cites odor trajectories in locust AL (2005). This was v inspiring as a biophysics student studying dynamical systems...

superb idea. we should be spending a lecture (at least) on this

Here it is finally: Our mathematical methods book for life scientists! Aimed at advanced undergrads and beginning grad students, plus all those who want a deeper look at the math behind quantitative biology. @portugueslab.bsky.social. 1/3

1/ Our paper appeared in @Nature today! www.nature.com/articles/s41... w/ Fiete Lab and @khonamikail.bsky.social . Explains emergence of multiple grid cell modules, w/ excellent match to data! Novel mechanism for applying across vast systems from development to ecosystems. 🧵👇

Announcing - the 3rd annual Midway Meeting of the Memory Minds (Mmmm)! Chicago-area memory neuroscientists, please join us for a day of talks, discussions, and a keynote by none other than @earlkmiller.bsky.social ! Registration is free, but space is limited. forms.office.com/r/rMxqDQ4sZF

Scoop --> Trump-Musk cuts just resulted in the firing of numerous top researchers at NIH's center for combating Alzheimer's, sources tell me. They predict big setbacks to fighting dementias. This cause was once championed by *Republicans.* Details here: newrepublic.com/article/1917...

We’ve got a new paper out today about hummingbirds and game theory. One of my co-authors, @kevinzollman.com, has written a very nice explainer thread here. 🪶

Nothing else to say.

Want to hear more about hippocampus-to-cortex feedback circuit? Our paper with the Basu lab is out in Nat Neuro! rdcu.be/eak1k . Well done Tanvi Butola!

"Scientists spend huge amounts of time trying to meet regulatory requirements instead of doing actual science, Dr. Droegemeier said." www.nytimes.com/2025/02/16/c...

I have been talking to the media, Time, Fortune, NBC, etc., to explain how the onslaught on science and NIH will impact the health of all Americans. Everyone knows someone who has cancer, heart disease, or depression. Spread the word about how cutting science impacts all. time.com/7216299/nih-...

Michelle Goldberg’s analysis is spot on - the Trump project for higher ed is to destroy it. 🎁 🔗 Why? A few thoughts 1/

Varmus: "the executive branch is waging war on America’s scientific enterprise...nominating leaders hostile to science and unqualified for their roles...This is not a fight that our country can afford to lose." www.nytimes.com/2025/02/14/o...

is anyone having a good time out there?

We are hearing that there is a meeting of all NIH IC directors happening now. We are also hearing, from several sources, rumors about director and assistant director level removals coming soon. The impact of this wld be enormous. IC directors have all grantmaking authority for each institute. 🧪

The “we don’t like DEI bc it puts unqualified people in charge of things” is such a WILDLY ironic perspective given just about every single appointment so far

Must-read for anyone interested in cognitive maps & the hippocampus.

Could be some useful news right now. We need it. popular.info/p/breaking-n...

Excerpt of an email from Northwestern re federal changes. Terrible news, especially on #1

NIH awards have quite literally flatlined since the change in administration. Council meetings, where the decisions on which grants to fund are made, are being canceled daily. No meetings, no decisions, no grants. The freeze is most definitely on, folks.

Relieved that the MOSAIC K99/R00 grants.gov page is no longer expired (updated today), and it sounds like people are able to submit apps again 🧪

NIH indirect changes paused nationwide now. www.statnews.com/2025/02/11/j...

Join us at the #LakeConference on Neural Coding & Dynamics in Seattle this September! @lakeconferences.bsky.social are small, active gatherings of researchers - each focusing on developing areas in neuroscience. All career stages welcome. 🧠📈 Apply by 5/23: alleninstitute.org/events/lake-...

BREAKING: Federal judge temporarily blocks NIH indirect costs rate cap issued Friday as applied to states that sued over the act this morning. Judge Angel Kelley, a Biden appointee, ordered further briefing as well, and set a hearing on Feb 21 in the case. storage.courtlistener.com/recap/gov.us...

BREAKING: 22 states sue NIH over Trump administration's new 15% cap on overhead for federal research grants. Suit filed federal court in Boston contends lifesaving research 'will grind to a halt' under the policy. Doc: storage.courtlistener.com/recap/gov.us...

Breaking news: 22 states are suing to block NIH’s cutting of indirect costs. See our updated story on the Friday night news and its aftermath. scim.ag/4hTJQ6v

"Polio: An American Story" describes how indirect costs became a thing. The precursor to the March of Dimes wanted to give a Harvard professor a grant to study polio. Harvard turned it down b/c they'd lose money by accepting the grant. The foundation offered to pay indirect costs and they accepted

The NIH announced it will slash billions of dollars of support to universities and research centers. This is one of the biggest attacks on science we have ever seen. It could dismantle the biomedical research system, shut down clinical trials, and halt development of treatments.

Can someone explain how likely it is that the 15% indirect cost change will actually go into effect? In a can’t-sleep panic (for the 373838th time since inauguration)

Flat 15% indirect costs across all grants (notes this will work because only 3 places - MIT, UMich, UAB - ever REFUSED a grant for lower than expected previous indirects). Impacts of this cut will presumably destroy research - current indirects are ~50%+ grants.nih.gov/grants/guide...

huge congrats!! have to plug CEBRA as an invaluable tool for our newest manuscript: "A universal hippocampal memory code across animals and environments" (which you can read here: www.biorxiv.org/content/10.1...)

This paper provides some evidence that hippocampal activity during reconsolidation is different than that when the memory is originally stored (suggesting an updated "engram"): www.cell.com/neuron/abstr... Reminds me of this old work from Kali & Dayan: www.nature.com/articles/nn1... 🧠📈 🧪

12 years ago today-- first day in the wilson lab :-p

genuine question: how are people getting work done when it feels like everything is a flaming garbage fire?

For all you place cell aficionados: there is a cool new preprint from my colleagues @mateneubrandt.bsky.social, @noralenkey.bsky.social and @koenvervaeke.bsky.social, showing that VIP interneurons gate place cell plasticity in the hippocampus! www.biorxiv.org/content/10.1...

!!!

New preprint: "The geometry of the neural state space of decisions", work by Mauro Monsalve-Mercado, buff.ly/42wVHD5. Surprising results & predictions! (Thread) We analyze neuropixel population recordings in macaque area LIP during a reaction time, random-dot motion 1/

I hope you will all join me in expressing your thanks to the NIH and NSF staff who are working in an impossibly difficult and chaotic environment to keep science going in our country.