dennishuang.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

New paper 📣! Pixelgen reports its incredible new Proximity Network Assay (PNA)->3D maps of 155 proteins in single cells by sequencing by barcoded antibodies and in situ rolling circle amplification yields >40,000 spatial nodes/cell: www.biorxiv.org/content/10.1...

submitted 4 hours ago • 1 comment

Now at molecular mechanisms in evolution GRC! Please stop by my poster tmr #1 and Mon/Tues #52! Will be presenting the Synergistic tuning of intramolecular feed-forward regulation shapes adaptive response of photoreceptors through domain co-evolution! Also see an earlier thread here:

submitted 3 days ago • 0 comments

Happy to announce our paper comparing embryonic gene expression between C. elegans and C. briggsae, work led by Christopher Large with Rupa Khanal and in collaboration with Junhyong Kim and Bob Waterston. www.science.org/doi/10.1126/...

submitted 4 days ago • 5 comments

🐠🦠Why can’t bacteria swim like fish? At microscopic scales, physics changes — viscosity rules! Researchers at our institute study how microbes like E. coli overcome this challenge with clever strategies like run-and-tumble. Watch our new video: youtu.be/drwCRRD7CGY?...

submitted 8 days ago • 3 comments

Beautiful work Kalli and team! Congrats!🎉

submitted 8 days ago • 1 comment

www.nature.com/articles/s41... Wild that loss of Y chromosome seems contagious 🤯

submitted 9 days ago • 0 comments

Thanks for the invite! Really enjoyed the talks!

submitted 13 days ago • 0 comments

Synthetic biology could enable new types of programmable therapeutics. Our new preprint introduces synthetic protein circuits that selectively trigger cell death in Ras-mutant cancer cells, with interesting advantages compared to existing approaches. www.biorxiv.org/content/10.1...

submitted 22 days ago • 3 comments

Crazy…

submitted 27 days ago • 0 comments

Nature research paper: Chromatin loops are an ancestral hallmark of the animal regulatory genome https://go.nature.com/4kcNObU

submitted 49 days ago • 1 comment

🤯🤯 Fun fact about Botrytis cinerea (where we got BcLOV4 from!): they randomly split their genomes to different nuclei

submitted 37 days ago • 0 comments

Science.

submitted 40 days ago • 0 comments

Beautiful conceptual work here. Challenging mainstream world view of oncogenes being deterministic and with an average effect of promoting cancer. In fact rare stochastic escape from homeostasis might be enough for tumor progression.

submitted 42 days ago • 0 comments

Was a great first day of workshop at the intersection of cancer initiation, sysbio, and synbio! Looking forward to tow more days!

submitted 42 days ago • 0 comments

Are you interested in synthetic and systems biology approaches to study #spatiotemporal processes in cancer? Join NCI for virtual workshops on May 13, 15, & 20 (next week!) from 12:00–4:30 PM ET: registration: events.cancer.gov/nci/syntheti... #SynSysBio4SpatialCancerResearch

submitted 47 days ago • 1 comment

We have updated our database of funding opportunities for Early-Career Researchers (private foundations, federal, international) We have 456 entries, for which we provide $ amount, deadline, eligibility criteria, etc. Download this massive database here for free: research.jhu.edu/rdt/funding-...

submitted 49 days ago • 3 comments

Check out our Aviatar toolkit for optogenetic translocation to arbitrary organelles! Simple, modular, compact, and many more.

submitted 56 days ago • 1 comment

Nature research paper: Low overlap of transcription factor DNA binding and regulatory targets https://go.nature.com/4jedGUz

submitted 69 days ago • 0 comments

Super cool work from Toettcher lab turning a sensor into an actuator!

submitted 60 days ago • 0 comments

Pulsatory response of the BcLOV4 photoreceptor through intramolecular feed-forward regulation https://www.biorxiv.org/content/10.1101/2025.04.08.647774v1

submitted 72 days ago • 1 comment

The pyroptosis circuit looks impressive!

submitted 61 days ago • 0 comments

How can an individual protein show adaptation? The light- and temp-sensitive BcLOV4 gives a pulse of translocation during a step input of light. Answer in our preprint: intra-molecular feed-forward regulation. bit.ly/3Rg9veD A @bugajlab.bsky.social collab with @nmrkaygee.bsky.social 🧵

submitted 71 days ago • 1 comment

BioMed X is launching a crowdsourcing platform to help researchers who lost NIH funding to find funders in the global pharmaceutical industry. 👍 bio.mx/news/press-r...

submitted 77 days ago • 0 comments

Excited to share that our protein editing method from the Muir Lab is now published in @science.org We believe that protein transposition will enable new biochemical studies of PTMs and open up new intersections of proteins and small molecules www.science.org/doi/10.1126/...

submitted 82 days ago • 2 comments

Latest from our lab! Sth I cannot live without for a week now! Stay tuned on more discoveries from ThermoPlate! Huge congrats to Will!

submitted 100 days ago • 0 comments

Wild, wondering why conceptually cancer evolve this way

submitted 101 days ago • 0 comments

www.nature.com/articles/s41... Pretty wild but makes a lot of sense that proteasome turns the whole proteome into a defense system during infection

submitted 110 days ago • 0 comments

Excited to share a new preprint! Wireless devices use FM modulation to transmit multiplexed noise-resistant data. Led by @born2raisecell.bsky.social, we create a biochemical analogue of this paradigm using genetically encoded oscillators (GEOs) for single-cell FM streaming tinyurl.com/nbs8rw42 🧵

submitted 113 days ago • 2 comments

Beautiful piece about problem choice in science and engineering. Intuition pumps, idea evaluations, parameter fixing/floating, altitude dance, reseeking a problem. www.cell.com/cell/abstrac...

submitted 113 days ago • 0 comments

NIH grants peeps are working hard, on a Sunday night, trying to get our grants out to us as their world is in chaos. We owe them all a huge debt. Science peeps: be sure to send your grants personnel (grants management, POs and SROs) a note of encouragement and gratitude. @sarathomasy.bsky.social

submitted 128 days ago • 2 comments

Excited and grateful that our initial report on temperature-sensitive protein switches is now published @naturemethods.bsky.social Co-led by PhD students Will Benman and @dennishuang.bsky.social www.nature.com/articles/s41... Brief thread:

submitted 152 days ago • 2 comments

Our paper on thermogenetic control of cells is out @naturemethods.bsky.social! General purposed for enzymatic reactions, signaling, cell fate control! Stay tuned on how BcLOV4 processes multiple input/out and gives pulsing activities!

submitted 152 days ago • 1 comment

Curious about how its 16 color vision is evolved… Is the distribution of number of colors an organism can perceive a continuous spectrum in nature? Also, how does it resist heat stress caused by its own strikes? theoatmeal.com/comics/manti...

submitted 157 days ago • 0 comments

Scientists are starting to study—and debate—how the unique features of Bluesky might affect discussions of research and workplace culture, and efforts to engage with the public. scim.ag/428RTYG

submitted 167 days ago • 4 comments

www.science.org/doi/pdf/10.1... Really cool work from @bashorlab.bsky.social and Xiaoyu Yang!

submitted 171 days ago • 0 comments