drsimonmcarthur.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

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submitted 12 days ago • 1 comment

One week left to get your applications in for this exciting PhD studentship fully-funded for students eligible for UK fees. Deadline: 31st January 2025 www.findaphd.com/phds/project...

submitted 33 days ago • 0 comments

Every week, I see a new study talking about this or that effect of GLP-1 receptor agonists like #ozempic. FINALLY, we have a study evaluating all the outcomes (good and bad) in one dataset. There are some... surprises. 🧵

submitted 35 days ago • 7 comments

Are you using 5xFAD mice to study Alzheimer’s disease? Our work out today @cp-neuron.bsky.social may be relevant to you 🐁🧠 Age and sex are known to influence Aβ plaque burden in these mice. Here, we found that the transgene parentage is another strong determinant. Thread below: (1/11)

submitted 37 days ago • 3 comments

A fascinating 2023/24 study of publishing timelines over 140,000 academics in STEMM showing discipline & country-specific attrition of academic careers from the publication of first paper. The probability of continuing after 19y just 38-43%. Interactive maps at: public.tableau.com/app/profile/... 🧪

submitted 45 days ago • 6 comments

Nice review highlighting the associations between neuropsychiatric conditions and #cerebrovascular deficits doi.org/10.1111/eci.... #BloodBrainBarrier #Psychiatry

submitted 49 days ago • 1 comment

Dr Cara Croft @caracroft.bsky.social & Dr Sarah Morgan @qmul.ac.uk are seeking a PhD Student to use high-resolution spatial transcriptomics to understand selective vulnerability to LBD pathology in Parkinson’s. Closing date: 31 Jan #PhDposition www.dementiaresearcher.nihr.ac.uk/job/phd-high...

submitted 50 days ago • 0 comments

New study on the pathogenic role of hypoxia in #BloodBrainBarrier disruption, with implications for vascular dementia #cerebrovascular academic.oup.com/braincomms/a...

submitted 53 days ago • 0 comments

Only a few days remaining to apply for a #PhD with me at the #EPSRC funded QMUL #CDT. The project involves working on the host-microbe interactions in the human mouth using novel #3D #organotypics / #organchip models #metabolomics Deadline is Monday, January 6th, 9am.

submitted 55 days ago • 0 comments

🚨Deadline is 6th Jan to apply for a PhD with me and @drsimonmcarthur.bsky.social, at the EPSRC funded QMUL CDT. Come and work on the host-microbe interactions in the human mouth with us at the @qmul-coirm.bsky.social group based in the Blizard Institute! #PhD #3D #organotypics #metabolomics

submitted 71 days ago • 0 comments

New research by @drsimonmcarthur.bsky.social and colleagues at Nottingham Trent University has found that a toxin found in the blood of patients with chronic kidney disease (#CKD) damages the body’s protective blood–brain barrier, likely contributing to the risk of #stroke.

submitted 72 days ago • 1 comment

Bit of commentary on fantastic exciting area using antibodies in Dentistry. Prof Takahashi group in Japan leading the way. Will follow this research closely. Immunotechnology in Dentistry coming of age. One day maybe even collaborate? www.france24.com/en/live-news...

submitted 74 days ago • 1 comment

Immunologists, time to embrace your inner neuroscientist 🧠🧪 Macrophages (yes, #macrophages) release glutamate (yes, #glutamate) to sensory neurons engaging in the muscle stretch reflex. Very cool paper! #neuroscience #immunology www.nature.com/articles/s41...

submitted 77 days ago • 2 comments

it's big, and it's a review of 601 papers on the topic - but here's an update on Neuroinflammation in Alzheimer's Disease www.nature.com/articles/s41... led by Michael Heneka, published in @natrevimmunol.bsky.social today (MANY more authors listed and linked below)

submitted 78 days ago • 1 comment

Monoclonal antibodies in #Alzheimers clear amyloid plaques and increase Aβ42. High Aβ42 levels improve cognition. Removing amyloid comes with risks: brain edema ('ARIA') and faster brain atrophy. The trade-off is not worth it. A nice summary @psypost.bsky.social www.psypost.org/neuroscienti...

submitted 79 days ago • 2 comments

#microbiomesky - please pass on to any potential PhD students interested in a (fully funded) project studying host-microbe interactions in the mouth

submitted 79 days ago • 0 comments

🎓 PhD Opportunity with me! 🚀 📢 Calling for aspiring bioengineers to join us! Develop organotypic models to explore host-microbe dynamics due to metabolic signals. Work with tissue systems, biofilms, imaging, and mass spectrometry. 💡Get in touch, and apply here: www.cpm.qmul.ac.uk/cdt/applicat...

submitted 79 days ago • 0 comments

Welcome to the European Microglia Webinar Series! Here you will find the information and link to every webinar, so dont forget to follow us

submitted 84 days ago • 2 comments

Over 7M people in the UK are estimated to live with #CKD. Researchers at #COIRM found a #gut #microbiome toxin in #CKD patients, p-cresol sulfate, damages the blood-brain barrier risking stroke & cognitive decline, but promising drugs may block this. More here: www.tandfonline.com/doi/full/10....

submitted 83 days ago • 0 comments

Nice write-up of our work from NTU's press office. @drsimonmcarthur.bsky.social @dvauzour.bsky.social

submitted 86 days ago • 0 comments

OK If we are moving to Bluesky I am rescuing my favourite ever twitter thread (Jan 2019). The renamed: Bluesky-sized history of neuroscience (biased by my interests)

submitted 87 days ago • 14 comments

@astephen.bsky.social - seen this?

submitted 88 days ago • 1 comment

📢Utmost importance the #food we eat & the #GutMicrobiota we have‼️ 👉#Gut #physiology & #environment explain variations in human gut #microbiome🦠 composition & #metabolism🆕🔥 @naturemicrobiol.bsky.social 🔍Zoom in to uncover the insights within 👉https://www.nature.com/articles/s41564-024-01856-x

submitted 89 days ago • 0 comments

New translational study from @bugsinyourguts.bsky.social and @drsimonmcarthur.bsky.social (at QMUL) showing how a microbiome-associated metabolite implicated in chronic kidney disease affects the blood–brain barrier. #microbiomesky

submitted 93 days ago • 0 comments

Brand new paper from our group! www.tandfonline.com/doi/full/10.... with @bugsinyourguts.bsky.social, looking at the role of the #gutbrainaxis and the #bloodbrainbarrier in #chronickidneydisease, and how we could protect it. Only started the work in 2016 - I blame (hand waves) everything... 1/5

submitted 93 days ago • 1 comment

Huge thank you to David Vauzour at UEA for quantifying pCS in patient samples, and colleagues from The William Harvey Research Institute for providing us with patient samples. Systems-level microbiome research only works when it's collaborative.

submitted 93 days ago • 0 comments

🧵 on our (@drsimonmcarthur.bsky.social) work showing the mechanism through which the microbiome-associated metabolite p-cresol sulfate damages the blood-brain barrier in chronic kidney disease (CKD). #microbiomesky #gutbrainaxis

submitted 93 days ago • 0 comments

Delighted to see this out, after a 2-year-long review process that left @drsimonmcarthur.bsky.social and I wondering what we'd done to upset the reviewing gods. #microbiomesky #gutbrainaxis www.tandfonline.com/doi/full/10....

submitted 93 days ago • 0 comments

In patients with chronic kidney disease you see high circulating levels of 3 microbiome-associated metabolites: indoxyl sulfate, TMAO and p-cresol sulfate (pCS). We'd looked at all, but found pCS damaged the blood-brain barrier in vitro, and had a long-lasting effect in vivo.

submitted 93 days ago • 1 comment

Transcriptome-based analyses of mouse brain tissue showed pCS affected lots of different things, but didn't highlight any specific pathway to look at, so @drsimonmcarthur.bsky.social hit the literature and found pCS interacted with EGFR. So this became the focus of his mechanistic work.

submitted 93 days ago • 0 comments

Activation of EGFR signaling --> activates annexin A1 and STAT3 --> mobilises matrix metalloproteinase MMP-2/9 --> damages the blood-brain barrier. The effect can be recapitulated with serum from dialysis patients, and blocked by EGFR inhibitors.

submitted 93 days ago • 0 comments

Patients with chronic kidney disease (CKD) are more prone to brain bleeds and stroke than the general population. We think that use of EGFR inhibitors (already used clinically) in these patients could protect them from some of the neuro effects of CKD. Translational gut-brain axis work. :)

submitted 93 days ago • 0 comments

Crazy stuff in PNAS dental plaque bacterium 𝘊𝘰𝘳𝘺𝘯𝘦𝘣𝘢𝘤𝘵𝘦𝘳𝘪𝘶𝘮 𝘮𝘢𝘵𝘳𝘶𝘤𝘩𝘰𝘵𝘪𝘪 can divide into an unprecedented 14 daughter cells at once—then each daughter cell starts growing immediately in a rare process called multiple fission, achieving 0.5 mm per day of expansion www.snexplores.org/article/bact...

submitted 96 days ago • 17 comments

Our new perspective on prebiotics and cognition in Advances in Nutrition. In this piece, led by @bdalile.bsky.social and ILSI Europe, we asked why given what we know about the #gutmicrobiota and the #gutbrainaxis, #prebiotics only show limited cognitive benefits? doi.org/10.1016/j.ad... 🧪🧠🦠

submitted 100 days ago • 2 comments