nehaghosh.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

What do we see when looking at cells under the microscope? 👉Some are bigger than others, some are elongated and align with the neighbors & others seem to move. Cool, right? But wouldn't it be cooler to quantify these observations? I'm @juliaeckert.bsky.social. Let's explore some analysis software!‬

submitted 5 days ago • 1 comment

Great new DNA/Q-Paint method published by our @ucl colleague Sabrina Simoncelli - lucky to have been part of it! Check out the Ecadherin and collagenIV imaging in the fly retina at up to 15micron depth www.nature.com/articles/s41...

submitted 14 days ago • 0 comments

Our new review paper from @yap-lab.bsky.social is online - together with Virgile Viasnoff! 👉 'New directions in epithelial mechanoadaptation' www.sciencedirect.com/science/arti...

submitted 19 days ago • 0 comments

Delighted that our work on positional memory is now published. We asked how axolotl cells 'know' which part of the limb to regenerate after injury. www.nature.com/articles/s41... A joy to work with super team Sarah Plattner, Yuka Sugiura, Francisco Falcon and Elly Tanaka. 🧵1/14

submitted 22 days ago • 21 comments

Many cells during development are exposed to caspase activation and yet survive. Why some die and not others ? We found out that the memory of previous caspase activation bias significantly later death comitment and bias death distribution and single cell decision www.biorxiv.org/content/10.1...

submitted 22 days ago • 9 comments

#Phosphofructokinase (PFK) is considered an irreversible glycolytic #enzyme. This study shows that #Trypanosomes are the only known organism to use PFK in the gluconeogenic direction under normal conditions, likely due to its compartmentalization within glycosomes @plosbiology.org 🧪 plos.io/43r84Qc

submitted 24 days ago • 0 comments

High-resolution optical imaging of the meninges within the brain of an adult zebrafish. Credit to @zebrafish007.bsky.social & #WeinsteinLab. #ZebrafishZunday 🧪

submitted 32 days ago • 3 comments

Who doesn't like looking at stunning images showcasing the beauty of #DevBio?? 😍

submitted 29 days ago • 0 comments

Unravelling a signalling pathway A new study reveals the network of molecules recruited by the signalling protein FGF during lens development. #DevBio

submitted 31 days ago • 0 comments

Hello, Bluesky! We’re FASEB—a federation of scientific societies advancing health & well-being by promoting biological & biomedical sciences through collaborative advocacy & service to our member societies. We’re excited to join this community. Let’s connect & amplify science together! www.faseb.org

submitted 87 days ago • 1 comment

Titin evolution, titin force and muscle contraction instruct sarcomere dimensions in insect muscles to allow high frequency flight, larval crawling and max force to cut leafs. @ibdm.bsky.social @mpi-nat.bsky.social @jfrupprecht.bsky.social @vincent-loreau.bsky.social www.science.org/doi/epdf/10....

submitted 33 days ago • 3 comments

How does transcriptional patterning regulate #SalivaryGland #morphogenesis? Annabel May & @katjaroeper.bsky.social use #scRNAseq of early morphogenesis of the #Drosophila salivary gland placode to reveal regulation by induction & exclusion of regulatory factors @plosbiology.org 🧪 plos.io/4cUw827

submitted 50 days ago • 0 comments

#MetabolismMondays has been one of the most read articles of April at @the-node.bsky.social !! Check it out now 👇🏽 thenode.biologists.com/all-the-worl... Check out the #ECR features so far - thenode.biologists.com/of-tor-and-t... thenode.biologists.com/the-fat-of-t... #devbio #cellbio #genetics

submitted 34 days ago • 0 comments

Design principles of cell-state-specific enhancers in hematopoiesis @cellcellpress.bsky.social www.cell.com/cell/fulltex...

submitted 35 days ago • 0 comments

Excited that our work revealing the structure and function of the monster stress response silencing factor, the E3 ligase SIFI, is now out! Congratulations to the most amazing team of Zhi Yang, Diane Haakonsen, Michael Heider and Sam Witus! www.nature.com/articles/s41...

submitted 36 days ago • 1 comment

Hot off the press: The excellent Maheva Andriatsilavo and colleagues show how a temporal sequence of stochastic molecular mechanisms allow the emergence of stereotyped individualised neuronal circuits. Just published in Nature Neuroscience: rdcu.be/ek010

submitted 36 days ago • 4 comments

My first post on Bluesky! Very excited to share our work just published in @science.org. We find that “Interphase cell morphology defines the mode, symmetry, and outcome of mitosis” - in angiogenesis and other tissues! www.science.org/doi/abs/10.1... www.science.org/doi/abs/10.1...

submitted 37 days ago • 3 comments

New lab preprint! High resolution mapping of the actin fusion focus reveals myosin V-dependent transport of formin for actin aster compaction. A very cool work led by @valthomas.bsky.social and nice collaboration with Andrea Picco and @kaksonen.bsky.social! www.biorxiv.org/content/10.1...

submitted 42 days ago • 2 comments

Cell-cell contacts orchestrate tissue assembly and diverse cellular interactions. 🎯But what mediates their intricate patterns?🤔 Join me, @feyzanar.bsky.social, in exploring the interplay of adhesion and subcellular mechanics in contact patterning.

submitted 41 days ago • 1 comment

New lab paper out! 😀 We describe a new benchtop technique to isolate microRNAs from various cell types in a complex tissue (like the developing CNS). This is a fruitful collab with the Cremer lab from @ibdm.bsky.social journals.plos.org/plosgenetics... 1/n 🧵

submitted 43 days ago • 3 comments

Excited to share my PhD paper is out! We studied how motion vision is processed beyond the optic lobes to help flies walk straight. It has been a wonderful collaboration with @michaelreiser.bsky.social, @dddavi.bsky.social and many others not in bluesky! Paper + digest here: bsky.app/profile/cham...

submitted 42 days ago • 4 comments

TF2TG: an online resource mining the potential gene targets of transcription factors in Drosophila. Hu Y, Rodiger J, Liu Y, Gao C, Liu Y, Qadiri M, Veal A, Bulyk ML, Perrimon N. Genetics. 2025 May 2:iyaf082. doi: 10.1093/genetics/iyaf082. Online ahead of print. PMID: 40314147

submitted 41 days ago • 0 comments

The head of a zebrafish embryo (72 hpf) photographed through a microscope. Yes, its eye follows you..... #CellBiology

submitted 42 days ago • 0 comments

I had some absolutely incredible papers come online this week, and I need to take a minute to post about each of them. First, let me tell you about the CarboTag probes for imaging plant cell walls! From the Sprakel lab (a short thread) www.nature.com/articles/s41...

submitted 42 days ago • 3 comments

This issue has become more acute in recent years. A narrow view of "mechanistic" experiments holds us back. "A case for broadening our view of mechanism in developmental biology" journals.biologists.com/dev/article/...

submitted 42 days ago • 0 comments

This week in Science, researchers delve into the #mathematics that shapes growing rose petals. 🌹 Explore our latest issue—featuring a new print design: scim.ag/42DasUT

submitted 42 days ago • 0 comments

This time-lapse captures 17 hours of axonal growth from a chicken dorsal root ganglion explant, visualized through the actin cytoskeleton using live confocal imaging. I just submitted this video to the Nikon Small World in Motion competition. Today is the last day to upload yours! 😉 🧪

submitted 44 days ago • 69 comments

Current methods for profiling #HistoneModifications require cell isolation & don't work with all tissue types. @jellevda.bsky.social &co adapt Targeted DamID (TaDa) to profile cell-type-specific #histone marks throughout the genome, in vivo, without cell isolation 🧪 @plosbiology.org plos.io/3Dw8sUD

submitted 43 days ago • 0 comments

Comprehensive mapping of protein-protein interactions in the Drosophila piRNA pathway reveals how adaptive evolution contributes to rapid diversification of this genome-defense mechanism Peter Andersen @germline.bsky.social and collaborators www.embopress.org/doi/full/10....

submitted 48 days ago • 1 comment

How do #cancer mutations cooperate with inflammatory cues in cancer? @rustenlab.bsky.social &co show that oncogenic Ras engages #inflammation to promote #tumor progression in flies, with Toll-NFκB signaling playing a key role in malignant progression & invasion @plosbiology.org 🧪 plos.io/3RGWESS

submitted 45 days ago • 0 comments

It is my pleasure to share our latest paper on basal transcription factor TFIID and biomolecular condensates! We found that the TFIID subunit TAF2 partitions into nuclear speckles and influences alternative splicing. doi.org/10.1016/j.ce...

submitted 47 days ago • 4 comments

A reviewer asked: but why is IRE1 activated when glucose is low? A committee member for Mabel Cruz's PhD asked: why is the UPR activated upon glucose deprivation? So we wrote a review about it. Here it is! @ericchevet.bsky.social @febsj.bsky.social febs.onlinelibrary.wiley.com/doi/10.1111/...

submitted 49 days ago • 2 comments

How can a cell control the size of its organelles? Excited to share a mechanism to control droplet size we recently found. a 🧵 www.nature.com/articles/s41...

submitted 48 days ago • 1 comment

New preprint! We have discovered that the splicing factor Sex lethal (Sxl - well known for its role in sex determination) binds to chromatin and regulates tRNA synthesis in neurons by interacting with RNA Pol III! Highlighting Sxl as a novel modulator of neuronal homeostasis. tinyurl.com/s44s2z95

submitted 47 days ago • 3 comments

#FluorescenceFriday the beautiful geometry of the capillaries of the retina👁️ Colors=depth. @cvsuor.bsky.social @urneuroscience.bsky.social @flaumeye.bsky.social @uofrbme.bsky.social @bpodaily.bsky.social @urochester.bsky.social

submitted 49 days ago • 2 comments

So happy to share that our review on epithelial cell extrusion is out! @levayerr.bsky.social Extrusion is such a plastic, context-dependent process, so capturing it visually in the poster that accompanies the article was a super challenging but fun task! journals.biologists.com/jcs/article/...

submitted 49 days ago • 1 comment

A trial has drawn links between fibromyalgia and alterations of the gut microbiome https://go.nature.com/3EDZxkv

submitted 49 days ago • 4 comments

A dream come true: the first expansion microscopy images of C. flexa 🤩 Generated by Mylan & Uzuki who learned from the best (@hiralshah.bsky.social @gautamdey.bsky.social @dudinlab.bsky.social). We will learn so much from these!

submitted 51 days ago • 18 comments

Fagotto, F. (2014). The cellular basis of tissue separation. Development, 141(17), 3303–3318. #EpithelialMechanicsReview doi.org/10.1242/dev....

submitted 49 days ago • 1 comment

mChartreuse & mLychee, for the bougiest (and brightest) transgenic bacteria. Gorgeous colors!

submitted 49 days ago • 3 comments

Hey #Drosophila community. What's your favourite UAS-based membrane marker for live cell #microscopy ? I previously tried mCD8-eGFP but it seems to be stuck in the ER... I can pretty much only see endo-membranes. This is not helpful, since I want to see cell outlines. Any suggestions, ideas?

submitted 51 days ago • 8 comments

How do hydraulic forces impact critical processes such as tissue integrity, cell fate decisions, and embryo development? Hydraulics studies how fluids move and exert forces. Join me in exploring few articles on hydraulics in #EpithelialMechanics

submitted 68 days ago • 1 comment

1/14 “Epithelial” & “Mesenchymal” aren’t binary categories—they form a spectrum, or better yet, a multidimensional space. This becomes especially clear in collective cell migration, which often depends on a finely tuned degree of “mesenchymal-ness”. #cellbio #devbio #cellmigration

submitted 54 days ago • 3 comments