Profile avatar
nxn.se
Molecular cell biology and stats / ML, mostly scRNA-seq. Principal Scientist at Vevo Tx. https://www.nxn.se/archive
27 posts 818 followers 72 following
Prolific Poster

SCVI — Integrating or not? - www.nxn.se/p/scvi-integ...

Deep Learning is Not So Mysterious or Different - arxiv.org/abs/2503.02113 Section 8, listing properties unique to neural networks, is quite interesting.

Half-Life - www.filfre.net/2024/12/half...

After some months of lurking, finally launching my bsky account with my completed Lifetime Achievement Award #animation! Song by @neilcic.com #lemondemon #spiritphone I don't even gotta tell u CW for mild body horror & flashing colors

Strange New Rules - protocolized.summerofprotocols.com/p/strange-ne...

Discworld Rules - contraptions.venkateshrao.com/p/discworld-...

A pre-trained SCVI model of our Tahoe-100M cell atlas is now available as a HubModel! It can be used for gene expression visualization, differential expression, or cell clustering. Available at Hugging Face with instructions on how to load it (see thread)

RNA xkcd.com/3056

Cloud GPUs for SCVI - www.nxn.se/p/cloud-gpus...

The strength of a hand - www.nxn.se/p/the-streng...

#scRNAseq to the next level: www.biorxiv.org/content/bior.... Mindbogglingly 100M cell large dataset involving 50 cancer cell lines and 1,100 molecule perturbations 🤩 — an absolute feast for the data-hungry ML/AI field, poised to advance cell understanding and modeling.

Over a 1000 compounds :0 www.biorxiv.org/content/10.1...

This is huge! Single-cell transcriptomic data from over 100 million cells belonging to 50 different cancer cell lines that were subjected to more than 1100 pharmacological agents. Waiting to see the predictive models that will result from this initiative. #singlecell doi.org/10.1101/2025...

Amazing working with this team!

AI 🤝 Biology Tahoe-100M, the largest single cell dataset ever generated, has just been open-sourced as part of the @arcinstitute.org Virtual Cell Atlas Initiative in partnership with @vevotherapeutics.bsky.social We're excited to see how this transforms the use of AI in biology!

Exciting dataset! If you're looking for a complimentary scRNA-seq drug perturbations in healthy/primary tissue (PBMCs), check out our dataset with ~36% # drugs of Tahoe. proceedings.neurips.cc/paper_files/...

It is always exciting when I have to adjust the y-axis limits of this plot, but extra special this time having been part of this project at @vevotherapeutics.bsky.social! tinyurl.com/vevo-tahoe100

@thejohnnyyu.bsky.social, @therealnima.bsky.social, and I, are excited to tell you about Tahoe-100M! The largest publicly available single-cell dataset that measures the effect of 1200 genes on 50 cell line models. The Vevo team has outdone itself. #Tahoe100M www.biorxiv.org/content/10.1...

Watch @thejohnnyyu.bsky.social @therealnima.bsky.social (@vevotherapeutics.bsky.social), @pdhsu.bsky.social , Dave Burke and I (@arcinstitute.org) talking about virtual cells, and how #Tahoe100M, now on. @arcinstitute.org's Virtual Cell Atlas, can change the game! www.youtube.com/watch?v=ak_f...

🎉 Scanpy 1.11.0 is out! 🎉 just after reaching 2000 stars on GitHub! - sc.pp.sample replaces subsample with many new features - Sparse Dask support pca - session-info2 package for more reproducible notebooks See the release notes:

Join us Tuesday at 2025-02-18 18:00 CET! Marius Lange will speak about Moslin, a new algorithm to map cells across time and lineage. For more information, check out the GitHub: https://buff.ly/4hTO522 & publication: https://buff.ly/41gcQzZ

"Anything threatening to be a subculture is commodified before it can walk" - www.dezeen.com/2014/12/18/w...

Vevo Therapeutics 💙 NVIDIA Healthcare 💙 Open Source. And we love making history with other like-minded organizations. Thanks Parse Biotechnology for GigaLab, without which this would not have been possible. And to Ultima Genomics for the support. Press Release: www.prnewswire.com/news-release...

A month ago we @vevotherapeutics.bsky.social announced that we have generated the largest single-cell perturbation atlas in history, Tahoe-100M. Today, we announce that we will fully open-source Tahoe-100M in Feb, as part of a collaboration with NVidia health to train cell state models.

Metacrap: Putting the torch to seven straw-men of the meta-utopia - people.well.com/user/doctoro... The examples are an interesting trip down memory lane of technological and cultural issues in August 2001

After 4y in the making, I am super excited that my main PhD project is published 🎉🥳🎉🎉🥳 www.nature.com/articles/s41... LEMUR is a tool to analyze multi-condition single-cell data and model differential expression as a continuous function of the cell-state space. Some highlights⬇️

Every cell in our body is unique. EMBL researchers have developed a statistical tool – LEMUR – to compare tissues and organisms using single-cell RNA sequencing and use it for applications in human health and fundamental biological research. #AcademicSky 🧬🧪 www.nature.com/articles/s41...

Ralph M. Steinman: A man, a microscope, a cell, and so much more - www.pnas.org/doi/full/10....

Image analysis should be so easy now that PowerPoint / Keynote should have features to automatically detect lines, font sizes, baselines, indents, etc., to align pasted images correctly on the fly.

I was just looking at our @scverse.bsky.social zulip chat statistics and am super happy about our steady and healthy growth. The two bursts are our official launch in May 2022 and the inaugural scverse conference in September of 2024. Please join us! scverse.zulipchat.com

I made some boxes to store some Nikon lenses - makerworld.com/en/models/86...

To build disease-relevant models of the cell, we need perturbative data at scale + AI that can efficiently learn from that data. @vevotherapeutics.bsky.social may be the only team that is pushing the boundaries of both. This recognition from DataBricke is a testament to that dbricks.co/3DbIULQ

Parse Bio GigaLab and Vevo Therapeutics Tahoe-100 experiment open.substack.com/pub/albertvi...

We 💙 Single-Cell Data. So we built an atlas of it that goes beyond anything available publicly by a wide margin. Proud of our team! And thanks Parse Biosciences and Ultima Genomics for the support.

@thejohnnyyu.bsky.social, @therealnima.bsky.social , Kevan Shokat, and I are excited to announce a historic achievement by our team at @vevotherapeutics.bsky.social: tinyurl.com/4rrvap3t

Timescales in Cell Biology

I made an extension hood for a cheap spotlight: makerworld.com/en/models/83...

A meditation on all the small, nearly unconscious tasks and motions that you go through doing lab work. These were just off the top of my head, and there are plenty more (additions encouraged in the comments!)

I made a cupboard riser shelf for old fashioned glasses: makerworld.com/en/models/80...

Immune response enrichment analysis in Python - www.nxn.se/valent/2024/...

Single-cell metadata as language - www.nxn.se/valent/2024/...

Organizing scRNA-seq data with LaminDB - www.nxn.se/valent/2024/...

Detecting scRNA-seq study duplicates using sentence embeddings - www.nxn.se/valent/2023/...