pranea.bsky.social
Scientist investigating peroxisomes and metabolism and teaching Physiology at the University of Granada (Spain). Granada - BCN - NYC - CPH - Granada https://sites.google.com/view/perbiometlab/home
61 posts
541 followers
443 following
Prolific Poster
Conversation Starter
comment in response to
post
sí sí, 100% de acuerdo contigo, muy irresponsable
comment in response to
post
exacto, es el ejemplo perfecto. Años de duro trabajo para aportaciones que luego no se pueden usar en la solicitud
comment in response to
post
Ayuda que están forraos claro, pero han implementado muchas medidas que se podrían tomar aquí sin mucho coste. Yo ahora de vuelta en Granada, creo que no volvería, pero es por otras razones, si fuera laboral, Dinamarca 100%
comment in response to
post
Definitely not proved here, but to be fair authors mention that they are not showing that.
comment in response to
post
Hope you enjoy the reading and this information is helpful for your research. The final printed version will be available soon. Please get in touch with us for any doubt or inquiry! (12/n)
comment in response to
post
Reviewers here were of great help! Thank you! The additional experiments they suggested definitely helped to create a more defined picture of the changes induced by overfeeding and allowed us to observe a subtle increase in energy expenditure with overfeeding. (11/n)
comment in response to
post
The team was also composed of Camilla Lund (the master of mouse overfeeding), @lundjens.bsky.social, the amazing RMPP staff @metabolcenter.bsky.social (Christine, Morten, Thomas, Vibeke… and more!), @mkleinert.bsky.social with bomb calorimetry, and of course @clemmensenc.bsky.social (10/n)
comment in response to
post
This was a challenging study, where we had to fit our overfeeding setup into @sablesys.bsky.social metabolic cages, but eventually we made it work! :) Special mention to Charlotte Svendsen who mastered the overfeeding procedure quickly after I left the lab to start my PI adventure in Granada. (9/n)
comment in response to
post
More research is needed to see if these findings apply to humans, but it offers relevant knowledge to better understand how our bodies respond to a calorie surplus. There is time-resolved energy expenditure data during and after overfeeding for the first time! (8/n)
comment in response to
post
Overall, this study provides new insights into the body's complex response to overfeeding. The ability to regulate food intake seems to be the primary defense against weight gain in mice. We are still very intrigued by the biological mechanisms behind this response! (7/n)
comment in response to
post
What if part of the energy is being excreted during/after overfeeding? Well, fecal energy excretion actually decreased in response to overfeeding (at least during recovery)! Probably related to the fact that they are eating less (6/n)
comment in response to
post
Gene expression analysis in metabolic tissues revealed some interesting changes in transcriptional programs related to futile cycles (body using energy somehow like the guy in the GIF below), but the impact of these changes in the response to overfeeding remains to be determined. (5/n)
comment in response to
post
We also explored the role of adipose tissue thermogenesis, which is the process of heat generation in fat. UCP1 KO mice behaved similarly to wild-type mice when subjected to overfeeding at 22ºC. (4/n)
comment in response to
post
Overfeeding causes a robust decrease in food intake (this we knew), but also an adaptive increase in energy expenditure that is subtle with this duration of overfeeding. After overfeeding, the profound reduction in food intake seems to be the major driver of the recovery in body weight. (3/n)
comment in response to
post
Our overarching aim is to reveal the mechanisms that control fat mass and body weight. We use a mouse model of overfeeding to create energy imbalance and observe the natural response to overfeeding. In this study we focused on energy expenditure and excretion changes (2/n)