jamesdmanton.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

I am desirous of this rather impressive objective lens.

submitted 4 days ago • 0 comments

Now out in JACS. pubs.acs.org/doi/full/10.... Grateful to thoughtful reviewers who found some errors in our model and encouraged us to make a better one! A renaissance in magnetobiology is coming...

submitted 8 days ago • 0 comments

In a deviation from our previous updates, our automatic parameter-free deconvolution code is now slightly _slower_ than before (~4.5 %), but more robust for low SNR data. Standard: beryl.mrc-lmb.cam.ac.uk/rlgc_notebook/ Biggs-Andrews accelerated: beryl.mrc-lmb.cam.ac.uk/rlgc_notebook/

submitted 6 days ago • 1 comment

Need to play more with it but so far works great on this OPM data.

submitted 9 days ago • 1 comment

Introducing warpfield, an open source Python library for GPU-accelerated non-rigid 3D registration. Warps and aligns gigavoxel volumes within seconds (not hours). For 3D microscopy, region-to-region and cell-to-cell matching. A collaboration with @mh123.bsky.social 🚀 github.com/danionella/w...

submitted 11 days ago • 7 comments

Thanks to a dose of activation energy from @dpshepherd.bsky.social, I've finally cleaned up my Biggs–Andrews accelerated version of our automatic parameter-free deconvolution code and made it available at beryl.mrc-lmb.cam.ac.uk/rlgcba_noteb.... This is ~2.75× faster than the previous version. 1/4

submitted 14 days ago • 1 comment

Thanks to some CUDA trickery*, our automatic parameter-free deconvolution code is now ~3× faster than the previous version (~9× faster than the original) while still producing exactly the same results as before. Try it out for free using Google Colab at beryl.mrc-lmb.cam.ac.uk/rlgc_notebook/ 1 / 2

submitted 16 days ago • 4 comments

We are releasing a GPU-accelerated oblique interpolation library for oblique plane microscopy (OPM) volume reconstruction. It avoids aliasing and interpolation artifacts caused by rectilinear interpolation approaches. github.com/danionella/o...

submitted 17 days ago • 0 comments

We present: A deconvolution solution to aliasing confusion in apparently undersampled oblique plane microscopy doi.org/10.1101/2025... [1/8]

submitted 21 days ago • 1 comment

How does a fly’s nervous system differ by sex? 🧠🪰 Led by Tomke Stürner & Paul Brooks, Greg Jefferis’ group, the Drosophila Connectomics group (University of Cambridge) & global colleagues publish a new atlas, revealing sex-specific neurons driving distinct behaviours. www.nature.com/articles/s41...

submitted 23 days ago • 1 comment

Fully-funded and well-supported PhD opportunity for Black UK-domiciled students here at Glasgow University: www.gla.ac.uk/scholarships.... The main call for applications closed in January, but evidently 2 more places have become available - a potential open goal for a suitable applicant! [1/2]

submitted 24 days ago • 1 comment

After years parked at a Polara, I’m excited to share that my PhD work is finally out! We figured out why imaging at liquid helium temperatures wasn’t working—and how to fix it. 🔗 www.pnas.org/doi/10.1073/...

submitted 30 days ago • 2 comments

Happy to see my Postdoc work out @natbiotech.nature.com. Using HaloTag and synthetic fluorophores instead of FPs enables us to shift the spectral properties of kinase activity reporters (KARs) to the far-red 🔬. Huge thanks to everyone involved @jinzhanglab.bsky.social! www.nature.com/articles/s41...

submitted 32 days ago • 8 comments

The @embo.org practical course on #lightsheet #microscopy is back! Join us in #Dresden for 2 weeks with #your #samples, try the complete line-up of #lightsheet microscopes, tackle big data image analysis, sample prep, OA hardware & much more Apply now! Repost 🙏 meetings.embo.org/event/25-lsm

submitted 38 days ago • 1 comment

Following a helpful and pleasant peer-review process, our direct-view oblique plane microscopy manuscript has now been published in Optica: doi.org/10.1364/OPTI... Special thanks to the copy editor who let us keep our cheeky little acknowledgement of the enjoyableness of drinking a cup of tea.

submitted 51 days ago • 1 comment

I am happy to announce here our latest bioRxiv submission where we introduce a new concept for measuring the electric charge of molecules in solution using a plasmonic nanocavity: www.biorxiv.org/content/10.1...

submitted 54 days ago • 2 comments

Happy to share our work published in Nature Photonics: "Threading light through dynamic complex media". We show how to pilot beams of light through the most stable channels within moving scattering media. Special thanks to Chai, Christina & John from the Structured Light Group, Exeter! #Photonics💡

submitted 69 days ago • 1 comment

It feels a bit strange having such a watery liquid behave optically like glass... www.biorxiv.org/content/10.1...

submitted 72 days ago • 1 comment

Looks like Zeiss just released a Fourier light field (doi.org/10.1364/OE.2...) product: www.zeiss.com/microscopy/e... I'll be very interested to see how people get on with it.

submitted 78 days ago • 2 comments

Very cool preprint by my colleague Kate McDole and her postdoc Katie Goodwin @cellbiol-mrclmb.bsky.social using beautiful imaging and quantitative methods to understand the wondrous migrations of primordial germ cells in mouse embryos doi.org/10.1101/2025...

submitted 80 days ago • 1 comment

mScarlet3-M163H/M66Q #FluorescentProtein #GFP is reported as an exceptionally photostable red FP. I'm wondering if any of you have practical experience with it yet? @steveroyle.bsky.social @franbottanelli.bsky.social @joachimgoedhart.bsky.social @christlet.bsky.social @manorlaboratory.bsky.social

submitted 87 days ago • 4 comments

Multispectral imaging aficionados may be interested in the latest update to our multispectral experiment design tool, which includes some Cramér–Rao analyses (original derivation courtesy of Sjoerd Stallinga). Guide & more coming to a preprint near you soon. beryl.mrc-lmb.cam.ac.uk/calculators/...

submitted 94 days ago • 0 comments

For the past three years, I have been incredibly fortunate to collaborate with the outstanding scientific illustrator Alexey Chizhik (@alexeychizhik.bsky.social) on the cover designs for Biophysical Reports. His work is truly exceptional—be sure to check it out at alexeychizhik.com.

submitted 96 days ago • 1 comment

RMS Early Career Award: Applications deadline has been EXTENDED to 28 February! This is a great opportunity to receive recognition for your work - and a chance to win a cash prize 😀 Find out more and enter: rms.org.uk/resource/202... @rmsearlycareer.bsky.social @bioimaginguk.bsky.social

submitted 98 days ago • 0 comments

The self-driving multiscale microscope from @daetwylerstephan.bsky.social is out. It can image an entire zebrafish embryo longitudinally and follow a volume of interest over time with high resolution. We used it to study cancer-immune cell interactions. www.nature.com/articles/s41...

submitted 100 days ago • 5 comments