drtimothyli.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

ALIS-containing regimens achieved higher culture conversion in noncavitary nodular bronchiectatic cases of refractory MAC ⬆️CRP, cavitary disease, and clarithromycin resistance predicted persistent culture positivity 71.4% AMK-resistant isolates had rrs mutations doi.org/10.1093/ofid... #IDSky

submitted 7 hours ago • 0 comments

A challenging case of XDR Klebsiella pneumoniae empyema, with summary of its resistance mechanisms doi.org/10.1093/jaca... #IDsky

submitted 8 days ago • 0 comments

New guidelines for diagnosis and management of candidiasis from ECMM in cooperation with @ishamycology.bsky.social and @asm.org Led by @olivercornely.bsky.social @rosannesprute.bsky.social with contributions from >100 experts Author link: authors.elsevier.com/sd/article/S... #IDSky

submitted 15 days ago • 4 comments

Things We Do for No Reason: Routine use of antibiotics for acute uncomplicated diverticulitis (UD) ⭐️Non‐inferiority of non-antibiotic management of UD supported by 2 landmark RCTs ⭐️Selective (vs routine) use of antibiotics for UD recommended by societies incl AGA and ACP doi.org/10.1002/jhm....

submitted 23 days ago • 0 comments

Rethinking Antibiotic Prophylaxis for Spontaneous Bacterial Peritonitis in Patients with Cirrhosis ➡️Standard of care since the 1990s and is currently recommended by several major GI societies ➡️Weak supporting evidence ➡️No clear mortality benefit doi.org/10.1093/cid/... #IDSky

submitted 25 days ago • 7 comments

Treating acute cholangitis = adequate drainage + covering organisms from blood cultures Additional coverage of organisms only grown in bile results in ⬆️ antibiotic duration and 🏥 stay, but similar organ failure/mortality/re-intervention rates

submitted 30 days ago • 0 comments

Main clinical and histopathological characteristics of CMV end-organ disease doi.org/10.1007/s001... #IDSky

submitted 36 days ago • 1 comment

Summary of new antibiotic agents for the treatment of MDR Gram negative bacterial infections doi.org/10.1016/S014... #IDSky

submitted 42 days ago • 4 comments

Should we double the starting dose of rifampicin (600mg/d➡️1200mg/d) for TB? ➡️Current dose is a minimally effective dose ➡️Rifamycins display concentration-dependent killing ➡️Meta-analyses showed double dose likely is safe and marginally more effective doi.org/10.1093/cid/... #IDSky #TBSky

submitted 46 days ago • 1 comment

Updated recommendations of pneumococcal vaccinations from ACIP A single dose of PCV is recommended for all adults aged ≥50 years who are PCV-naive or who have unknown vaccination history dx.doi.org/10.15585/mmw... #IDSky

submitted 51 days ago • 0 comments

In patients with septic shock, ddPCR may diagnose bacteremia earlier than blood culture (BC) and with comparable accuracy. ➡️82.7% BC +ve cases were ddPCR +ve ➡️Those with septic shock had significantly higher levels of E. coli DNA doi.org/10.1186/s128... #IDSky

submitted 52 days ago • 2 comments

A scientific statement from AHA on prevention, diagnosis and management of CIED infection doi.org/10.1161/CIR.... #IDSky

submitted 54 days ago • 1 comment

AmpC-producing Enterobacterales: Expected phenotypes for wild-type strains and in cases of AmpC derepression and ESBL production doi.org/10.3390/phar... #IDSky

submitted 55 days ago • 2 comments

🆕🔥Just published 🔥🆕 Updates on the Treatment of Drug-Susceptible and Drug-Resistant Tuberculosis(TB) An Official ATS/CDC/ERS/IDSA Clinical Practice Guideline #idsky #TBsky www.atsjournals.org/doi/full/10....

submitted 57 days ago • 1 comment

Strategy for penicillin allergy delabeling by non-allergists For very low risk non-allergic index reactions, direct delabeling w/o testing is reasonable whereas a single step challenge may be considered for patients who are anxious or desire additional reassurance. doi.org/10.1016/j.ja... #IDSky

submitted 65 days ago • 1 comment

It's that time of year again. Here are my top 10 ID papers of 2024 1. My opinion 2. Practice changing, paradigm-shifting or dogma challenging 3. Not COVID 4. Alphabetical order by first author 5. CoI for 4 and 5 (I am an author) Summary slide here, details in thread #IDSky #Top10IDpapers

submitted 68 days ago • 12 comments

Many people talk about the "Golden Age of Antibiotics", but I hadn't seen it visualized properly. Just how many types of antibiotics were discovered during that time? So, I visualized it myself!

submitted 68 days ago • 24 comments

How do you dose linezolid when treating MDR-TB? Reducing linezolid to 300mg/d after 9-13 weeks of 600 mg/d is as effective as the standard 600mg/d for 26w but with ⬇️cases of peripheral neuropathy when given with bedaquiline and pretomanid (Median BW = 45kg) #IDSky #TBSky doi.org/10.1093/cid/...

submitted 72 days ago • 1 comment

How to manage spinal implant infections? Read all about it. #IDSky By yours truly. academic.oup.com/cid/article/...

submitted 73 days ago • 7 comments

Randomly saw this and realized shorter is better applies to 🐶 too Shouldn't be surprising right? doi.org/10.2460/javm... #IDSky @bradspellberg.bsky.social @paulsaxmd.bsky.social

submitted 76 days ago • 2 comments

🔥🔥 NEW 🔥🔥 Year In Review: Top Infectious Diseases Articles From 2024 Our new post, a great collaboration with my friend 🌟 @idstewardship.bsky.social 1️⃣6️⃣⚡️🆔 RCTs 7️⃣Syst Reviews/Meta 3️⃣🌏Guidelines ✨️Wiki_Guidelines #idsky #EMIMCC #medsky #utisky EnJoy Share plz! www.idstewardship.com/year-review-...

submitted 79 days ago • 10 comments

Characteristics of selected urine dipstick tests for diagnosis of UTI It has been used to rule out a UTI with a combination of negative results for both the nitrite and leukocyte esterase tests, but a positive result from either test alone cannot diagnose a UTI doi.org/10.1128/cmr.... #IDSky

submitted 80 days ago • 1 comment

🆕️✨️Retrospective cohort study Oral doxycycline for the treatment of ocular syphilis may be safe and effective as IV penicillin in a selected subset of patients who completed an extended oral antibiotic #idsky #medsky #AMSsky jamanetwork.com/journals/jam...

submitted 84 days ago • 2 comments

A Case of Quadruple-Valve Endocarditis😱 ➡️Recurrent Enterococcus faecalis bacteremia, 2 years after quadruple bioprosthetic valve replacement ➡️Negative TEE❗ ➡️PETCT: heterogenous FDG uptake on all 4 valves (vs homogeneous➡️reactive inflammatory change) doi.org/10.1016/j.ma... #IDSky

submitted 84 days ago • 0 comments

Pathobiology of sepsis doi.org/10.1056/NEJM... #IDSky

submitted 86 days ago • 0 comments

Again, early transition to oral antibiotics for bacteremia treatment should be the standard of care Bugs don't care how the drugs get there @bradspellberg.bsky.social

submitted 87 days ago • 0 comments

Zoonotic sporotrichosis from cats is not only found in the Americas Increasing numbers of cases have been found in Thailand🇹🇭 as well Most commonly affecting immunocompetent middle age female S.schenckii complex is suspected to be the main culprit doi.org/10.3201/eid3... #IDSky

submitted 87 days ago • 1 comment

Procalcitonin is far from being a perfect biomarker. But when used appropriately, it can be an effective anti-anxiolytic (i.e. ⬇️ unnecessary antibiotic use) This meta-analysis shows its role in cancer patients with suspected resp infections and sepsis doi.org/10.1186/s128... #IDSky

submitted 89 days ago • 2 comments

Flat dosing of pyrazinamide at 1000mg achieved a higher proportion of participants within the therapeutic window compared with weight-banded dosing and flat dosing at 1500mg Has anyone already switched to flat dosing of pyrazinamide at 1000mg/day for TB? doi.org/10.1164/rccm... #IDSky #TBSky

submitted 90 days ago • 5 comments

Endogenous endophthalmitis with subretinal and brain abscesses caused by Streptococcus Intermedius The patient presented with isolated ocular symptoms for 4 days with no prodromal systemic symptoms🤯 And the🦠was only found in pus from brain and eye (blood/CSF -ve)🤯 doi.org/10.1016/S147... #IDSky

submitted 92 days ago • 1 comment

Antibiotic Length Actually Needed for Heart Failure (ALAN-HF) #IDSky

submitted 93 days ago • 0 comments

POET group from 🇩🇰 ➡️ Following the POET trial, ⬇️ in median LOS 🏥 of 8 days with no change in mortality & an associated ⬇️ rate of relapse of bacteremia #IDsky #Medsky 🧵 (1/5)

submitted 95 days ago • 4 comments

Oral switch for endocarditis treatment whenever possible should be a standard of care "Following the POET trial, we found a reduction in median LOS of 8 days with no change in mortality and an associated lower rate of relapse of bacteremia." doi.org/10.1016/j.ja...

submitted 95 days ago • 2 comments

Differential diagnosis for fever in an ICU patient #IDSky #MedSky #SciArt

submitted 95 days ago • 3 comments