grahamerwin.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

As #AGBT approaches, discover how #PacBio SPRQ chemistry for Revio is advancing #HiFisequencing efficiency, reducing costs, and unlocking new research possibilities. bit.ly/4g89HXK #AGBT25

submitted 9 days ago • 0 comments

We are starting to see what "AI will accelerate science" actually looks like. This Google paper describes novel discoveries being made by AI working with human co-scientists (something I think we have all been waiting to see), along with an early version of an AI scientist for wider use.

submitted 9 days ago • 1 comment

At #BPS2025? Check out the posters by @sovannytaylor.bsky.social and @gtleung.bsky.social on Monday. Venom peptides as tools to study cell penetrance and designer condensates to probe cytoplasmic rheology across length scales.

submitted 13 days ago • 0 comments

Highly recommend the Unpaywall extension to access manuscripts — it's easier than Sci-Hub, and legal! unpaywall.org/products/ext...

submitted 13 days ago • 0 comments

Here’s my post on the NIH indirect costs slash-and-burn. God, these people are exhausting:

submitted 18 days ago • 3 comments

Another assault on US competitiveness at a time when biomedicine is roaring with innovation, an own-goal in a high-stakes international tournament. Of course the real losers are American people needing medicines and cures. www.washingtonpost.com/health/2025/...

submitted 20 days ago • 60 comments

You will never guess the report that took Deep Research the longest to generate of any I made before. 30 pages, 10,600 words, and actually super interesting to read based off a single prompt. Full report (and prompt): chatgpt.com/share/67a152...

submitted 25 days ago • 5 comments

A long post about what’s happening to the science funding agencies in the US and why. As mentioned, this one just kept getting longer even as I kept stripping curse words from it. www.science.org/content/blog...

submitted 24 days ago • 21 comments

Friends and colleagues, I’ve written a book on effective functional genomics study design, which will be available on Amazon in a couple of weeks. Sharing the TOC to spark interest. I hope students and those planning genomics experiments will find it useful! I’ll share updates soon

submitted 50 days ago • 6 comments

First real post on @bsky.app! Check out our latest work identifying covalent fragments as inhibitors of the Fph serine hydrolases in S. aureus. Great work from Tulsi Upadhyay and our many collaborators. www.researchsquare.com/article/rs-5...

submitted 50 days ago • 2 comments

Deeply saddened by the news of Fraser Stoddart’s passing. Here is a piece I wrote on the occasion of his 2016 @nobelprize.bsky.social at ACSCentSci. pubs.acs.org/doi/10.1021/...

submitted 59 days ago • 3 comments

'But that’s not the only reason Science has named lenacapavir its 2024 Breakthrough of the Year. The off-the-charts success of the drug as PrEP sprang from a basic research advance: a new understanding of the structure and function of HIV’s capsid protein, which lenacapavir targets'

submitted 58 days ago • 1 comment

🎶 Hark! The folded proteins sing, Stable chains and everything. Joyful folds in ribboned form, Structures bright, precise, and warm.* 🎶 Life depends on such designs, Aligned through microscopic lines. Peace on Earth and molecules bring, Hark! The folded proteins sing. 🎶

submitted 73 days ago • 0 comments

Turn a GitHub repo into a single text file for LLM-friendly input: app takes a GitHub repo URL, displays the directory structure, lets you choose which files to include, and provides a single plain text file you can feed into any LLM. blog.stephenturner.us/p/github-rep... w/ #rstats example

submitted 81 days ago • 6 comments

Apparently, Biorender now does graphing. Do not use. Terms of service likely include them owning your first-born child.

submitted 81 days ago • 1 comment

Models like o1 suggest that people won’t generally notice AGI-ish systems that are better than humans at most intellectual tasks, but which are not autonomous or self-directed Most folks don’t regularly have a lot of tasks that bump up against the limits of human intelligence, so won’t see it

submitted 84 days ago • 9 comments

Hello, #MedSky community! We’re excited to begin our Bluesky journey. Here is a sampling of the trusted, influential, and essential information you can expect when you follow us:

submitted 84 days ago • 32 comments

Scared to share this after 10 freaking years of waiting, but here we go: We found that temperature perception can change the biology of the next generations, even when “it’s just in the parents' head”. Read how C. elegans neurons control epigenetic inheritance! www.biorxiv.org/content/10.1...

submitted 85 days ago • 37 comments

Biology of Genomes 2025 is coming up: - meeting dates: May 6 - 10, 2025 - abstract deadline: Feb 14, 2025 We hope to see you there for another great meeting with a fantastic speaker lineup! meetings.cshl.edu/meetings.asp...

submitted 87 days ago • 1 comment

Scientists, academics, researchers: We’re excited to share that @altmetric.com is now tracking mentions of your research on Bluesky! 🧪

submitted 87 days ago • 479 comments

Fluorescently labeled proteins are essential to research. But we should never forget how messed-up their behavior can be. An example from condensates:

submitted 88 days ago • 9 comments

You probably aren’t being ambitious enough in your AI experiments. Start with completely out there applications, assess them, and then reign in your ambitions from there. You might be inspired or surprised about how good AI is, or you might discover useful limitations earlier.

submitted 88 days ago • 4 comments

Striking similarity of some of the genetic signals in mismatch repair genes (MSH3, FAN1 and PMS2) between GWAS of somatic expansion of CAG repeats in TCF4 gene (estimated from UKB WGS data) & GWAS of age at onset of cognitive changes in Huntington's. www.biorxiv.org/content/10.1...

submitted 92 days ago • 2 comments

Gene regulation involves thousands of proteins that bind DNA, yet comprehensively mapping these is challenging. Our paper in Nature Genetics describes ChIP-DIP, a method for genome-wide mapping of hundreds of DNA-protein interactions in a single experiment. www.nature.com/articles/s41...

submitted 94 days ago • 9 comments

Sometimes you just have to persevere through negative reviews. Reviewers, please be kind :) #methodsmatter bit.ly/gs2-scholar

submitted 96 days ago • 14 comments

🎨 In case anyone need… The NIH BioArt Source is an awesome library of free professionally drawn illustrations for scientific presentations or figures. Downloadable in HD. Thank you NIH for this invaluable tool 🙏! Check it out 👇 bioart.niaid.nih.gov

submitted 97 days ago • 45 comments

Excited to share our research has been highlighted in a @Tufts Now article! now.tufts.edu/2024/11/15/r...

submitted 105 days ago • 0 comments

Organizations (including university labs) should stockpile problems they could use help on from the new set of agentic & o1-like systems that are coming soon. I suspect that they will be less useful to non-experts at first, but open up some new opportunities for complex work that AIs can do.

submitted 98 days ago • 2 comments

What a fantastic day at Tufts University! Sergei Mirkin, Catherine Freudenreich, and @sarahhengel.bsky.social. What a special place.

submitted 98 days ago • 1 comment

Mass spec meme to get things started here 😆

submitted 100 days ago • 1 comment

The Long-read sequencing Special Issue is now LIVE! Guest-edited by @ahoischen.bsky.social , @sedlazeck.bsky.social, and @anaconesa.bsky.social.

submitted 100 days ago • 0 comments

Thanks @dereklowe.bsky.social for amplifying this fun piece in ACS Cent Sci. I shall think through my own eureka moments and make a contribution!

submitted 100 days ago • 3 comments

Single-molecule states link transcription factor binding to gene expression www.nature.com/articles/s41...

submitted 100 days ago • 1 comment

Long-read special issue of GR is out, including our paper on T2T assembly using only Nanopore. Just in time for ONT to discontinue duplex cells on Nov 27 😅😂 Good thing Verkko also works great with HERRO-corrected simplex data! 📄 genome.cshlp.org/content/34/1... 📖 genome.cshlp.org/content/34/1...

submitted 100 days ago • 4 comments

Yay!! @amerchemsociety.bsky.social is in the house clap👏

submitted 100 days ago • 2 comments

Our special issue @genomeresearch.bsky.social is out on long-read sequencing (@pacbio.bsky.social & ONT): genome.cshlp.org/content/34/1... Super excited about all the new work and special thanks to all the authors! Big thanks to Hillary @ahoischen.bsky.social @anaconesa.bsky.social

submitted 99 days ago • 1 comment

A thread on NIH Reorganization and the Scientific Management Review Board (SMRB) Disclosure: I was involved with the SMRB since its inception and have very strong feelings about how it was used, misused, and abandoned. My passion on these issues will undoubtably show through. 1/n

submitted 100 days ago • 18 comments

Our story in PNAS today! (1) anti-AR molecules with new mechanism: induction of chromatin binding YET a disruption of transcription (2) why only ~150 genes respond to AR ligands, despite the 6,000+ AR binding sites: they need 3D clustering to matter! www.pnas.org/doi/10.1073/pnas.2406239121

submitted 101 days ago • 1 comment

Very interesting paper by the group of Jack Taunton in Nature. They used salicylaldehyde-based reactive groups to develop mutant-selective AKT1 (E17K) inhibitors. Key to selectivity is a very slow off-rate from the mutant due to neo-zinc chelation. www.nature.com/articles/s41...

submitted 101 days ago • 0 comments

The first FDA-approved drug for frostbite can save limbs from amputation, and researchers are working on “coldscreen” preventatives. Check out "The Fight Against Frostbite Progresses" latest from @cenmag.bsky.social special for ACS Central Science. ❄️ pubs.acs.org/doi/10.1021/... #ChemSky

submitted 101 days ago • 1 comment

What mutations hides in our cells? We utilized Nanopore for WGS single cell sequencing to find out with @proukakis.bsky.social ! Interesting transposon patterns + repeat recombinations! www.medrxiv.org/content/10.1... Figs: SC deletion also present in bulk. Detection of SC vs. bulk SV

submitted 101 days ago • 0 comments