tarikavr.bsky.social
Consultant - cellular agriculture, synthetic biology, smart protein 🌾🔬🥘
👩🏽💻 I communicate the science of future food and biomaterials: https://medium.com/@tarikavr
🔗 https://www.trovebiosciences.com/
26 posts
245 followers
228 following
Regular Contributor
Conversation Starter
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Optimizing ER stress responses could unlock higher yields and further reduce production challenges in plant-derived biopharmaceutical products.
🔗pubmed.ncbi.nlm.nih.gov/38038125
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When producing mAbs (mAb1 & mAb2), the protein causing stronger ER stress led to necrotic symptoms and poor yields. This highlights the need to manage ER stress for efficient plant-based protein expression. 🌟
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🔗 Link to paper: medium.com/@tarikavr/i-...
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🏅 3. First-of-a-Kind Research:
Dog meat: Natural leaf veins used as scaffolds for cultured meat
Eel: Immortalized cell line for ethical eel meat
Crayfish: Stem cell research for seafood
Milk: Proteomics identified 900+ proteins for enhanced nutrition
#cultivatedmeat #cellag #proteindeeptech
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🐄 2. Bovine & Aquatic Research Dominates: Bovine myoblasts & myosatellite cells were key research targets for cultured meat production, while porcine fat stem cells were the focus of many studies. Unique aquatic models like crayfish and Japanese eel also gained traction in aquatic research. 🐠
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🔍 1. Research Growth & Global Trends: The past 5 years have seen a 400% growth in CM publications, with a 25% increase in technical research from 2023 to 2024. South Korea and China led this surge with significant contributions. Could this signal a rise in startups emerging from Asia? 🤔
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🙋♀️
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Agreed on both fronts. The CM academic landscape is also shaping research in parallel industries (eg: biopharma). More on that soon!
Thanks for engaging and please do let me know if you have any feedback for me :)
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1. Market Leaders: Helaina and TurtleTree
2. Cost Reduction: A. awamori can produce higher titers (> 5g/L) with relatively low cost ($1/g compared to $2-$6/g).
3. Investment Surge: >$160 million since 2019.
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⚙️ Innovations in the precision fermentation sector can help solve these issues.
A TL;DR on the recombinant Lactoferrin (rLF) landscape can be found here: medium.com/bioengineere...
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With rising demand in infant care and biopharma, traditional production faces challenges:
📉 Low Expression Levels: Cows produce <0.1 mg/mL, while breastfeeding humans can produce <5 mg/mL.
💲 High Costs: Priced at USD 400–3000/kg, producing 1 kg requires 10,000 liters of milk.
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Liked this TL;DR? Check out my Medium article to learn more: medium.com/bioengineere...
#CellularAgriculture #CultivatedMeat #FutureFood
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5️⃣ Biofabrication on the Rise: Techniques like bioprinting are enhancing the structuring of cellular aggregates, essential for scaling up production. Materials like plant-based carbohydrates are proving to be excellent for cell adhesion 🌳
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4️⃣ Evolving Cell Media: Transitioning away from serum-based media, new solutions include:
Recombinant FGF1: Enables serum-free cell proliferation.
Marine Algae: Promotes cell growth in a serum-free environment.
Egg White: Reduces serum usage by 50%.
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3️⃣ Innovative Scaffolds: New, cost-effective scaffolds are emerging: 🍄
Mycelium: Enhances growth and lowers production costs
Nanofibers: Cellulose acetate nanofibers (CAN) boost muscle cell differentiation.
Probiotic Bacteria: Potentially edible scaffolds for mammalian tissue culture.
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2️⃣ Geographic Leaders: South Korea and China are at the forefront, contributing over 50% of technical papers. South Korea’s new regulation-free zone and China's robust funding and incentives are driving this surge in innovation 🌏
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3. ~40 out of 50 companies utilize yeasts to produce PF derived ingredients. Some of these use a combination of yeast/bacteria/filamentous fungi 🍄
A mini deep dive: medium.com/bioengineere...
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2. High-value ingredients like lactoferrin and palm oil present opportunities for innovation and investments. 🌴
A mini deep dive: medium.com/bioengineere...
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Hey @elliotswartz.bsky.social, could you please add me to this list?